ArticleHeart and vessels2016
Characterization of cardiac oxidative stress levels in patients with atrial fibrillation.
Article in Heart and vessels, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Obesity and atrial fibrillation: a narrative review from arrhythmogenic mechanisms to clinical significance.Cardiovascular diabetology · 2023Review
- Lipidomic profiling reveals free fatty acid alterations in plasma from patients with atrial fibrillation.PloS one · 2018Article
- Cardiac hyaluronan may be associated with the persistence of atrial fibrillation.Heart and vessels · 2017Article
- Efficacy of Intravenous Administration of Landiolol in Patients With Acute Heart Failure and Supraventricular Tachyarrhythmia.Journal of clinical medicine research · 2017Article
- Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways.Heart and vessels · 2017Article
- Relationship between HRV measurements and demographic and clinical variables in a population of patients with atrial fibrillation.Heart and vessels · 2016Article
- Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).The American journal of cardiology · 2016Article
- Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.Heart and vessels · 2016Article
- Selective downregulation of mitochondrial electron transport chain activity and increased oxidative stress in human atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is associated with oxidative stress and elevated brain natriuretic peptide (BNP) levels. However, the exact cardiac origin of oxidative stress and its association with BNP levels in AF patients remain unclear. Therefore, we investigated the chamber-specific plasma oxidative stress levels in patients with paroxysmal AF (PAF) and persistent AF (PSAF). Diacron-reactive oxygen metabolite (dROM) levels were measured in patients with PAF (n = 50) and PSAF (n = 35) at different cardiac sites before ablation and in peripheral vein 3 months after ablation. For all sites, dROM levels were higher in PSAF patients than in PAF patients; the levels were the highest in the coronary sinus at 429.0 (interquartile range: 392.0-449.0) vs. 374.0 (357.0-397.8) Carratelli units (P < 0.05). dROM levels in the coronary sinus were related to the BNP levels (r = 0.436, P < 0.001). Furthermore, the reduction in the peripheral dROM levels was related to that in the peripheral BNP levels in patients with symptomatic improvement (r = 0.473, P < 0.001). Cardiac oxidative stress may either be a cause or consequence of prolonged AF, and cardiac oxidative stress levels correlated with BNP levels, though a possible source of oxidative stress in AF patients may be systemic circulation.
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