ArticleJournal of computational neuroscience2015
Model-based asessment of an in-vivo predictive relationship from CA1 to CA3 in the rodent hippocampus.
Article in Journal of computational neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming.Frontiers in neural circuits · 2024Article
- Ictogenesis proceeds through discrete phases in hippocampal CA1 seizures in mice.Nature communications · 2023Article
- A model of working memory for encoding multiple items and ordered sequences exploiting the theta-gamma code.Cognitive neurodynamics · 2023Article
- Multi-Input, Multi-Output Neuronal Mode Network Approach to Modeling the Encoding Dynamics and Functional Connectivity of Neural Systems.Neural computation · 2019Article
- Methodology of Recurrent Laguerre-Volterra Network for Modeling Nonlinear Dynamic Systems.IEEE transactions on neural networks and learning systems · 2017Article
- Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3.PLoS computational biology · 2017Article
- Hippocampal closed-loop modeling and implications for seizure stimulation design.Journal of neural engineering · 2015Article
- Harnessing the power of theta: natural manipulations of cognitive performance during hippocampal theta-contingent eyeblink conditioning.Frontiers in systems neuroscience · 2015Review
- Reproducibility and Temporal Structure in Weekly Resting-State fMRI over a Period of 3.5 Years.PloS one · 2015Article
- Understanding spike-triggered covariance using Wiener theory for receptive field identification.Journal of vision · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although an anatomical connection from CA1 to CA3 via the Entorhinal Cortex (EC) and through backprojecting interneurons has long been known it exist, it has never been examined quantitatively on the single neuron level, in the in-vivo nonpatholgical, nonperturbed brain. Here, single spike activity was recorded using a multi-electrode array from the CA3 and CA1 areas of the rodent hippocampus (N = 7) during a behavioral task. The predictive power from CA3→CA1 and CA1→CA3 was examined by constructing Multivariate Autoregressive (MVAR) models from recorded neurons in both directions. All nonsignificant inputs and models were identified and removed by means of Monte Carlo simulation methods. It was found that 121/166 (73 %) CA3→CA1 models and 96/145 (66 %) CA1→CA3 models had significant predictive power, thus confirming a predictive 'Granger' causal relationship from CA1 to CA3. This relationship is thought to be caused by a combination of truly causal connections such as the CA1→EC→CA3 pathway and common inputs such as those from the Septum. All MVAR models were then examined in the frequency domain and it was found that CA3 kernels had significantly more power in the theta and beta range than those of CA1, confirming CA3's role as an endogenous hippocampal pacemaker.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.