Evidence map›Paper›PMID 25260370›Full record

SynthesisBMJ open2014

Pain in patients with COPD: a systematic review and meta-analysis.

Eléonore F van Dam van Isselt, Karin H Groenewegen-Sipkema, Monica Spruit-van Eijk, Niels H Chavannes, Margot W M de Waal, Daisy J A Janssen, Wilco P Achterberg

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
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  13. Article
  14. Physical Activity, Depression and Quality of Life in COPD - Results from the CLARA II Study.International journal of chronic obstructive pulmonary disease · 2023
    Article
  15. Article
  16. Cross-sectional study of pain-related variables before and during the COVID-19 pandemic in patients with COPD.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022
    Article
  17. Article
  18. Review
  19. Clinical and Psychological Impact of Chronic Pain in People with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eléonore F van Dam van IsseltDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Karin H Groenewegen-SipkemaPulmonary Department, Deventer Hospital, Deventer, The Netherlands.
Monica Spruit-van EijkDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands Pulmonary Department, Deventer Hospital, Deventer, The Netherlands Department of Research and Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
Niels H ChavannesDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Margot W M de WaalDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Daisy J A JanssenDepartment of Research and Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands.
Wilco P AchterbergDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLCiro · NLDeventer Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo systematically investigate the prevalence of pain, factors related with pain and pain management interventions in patients with chronic obstructive pulmonary disease (COPD).

designSystematic review and meta-analysis. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: PubMed (MEDLINE), EMBASE, CINAHL and PsychINFO from 1966 to December 2013. Studies were included if they presented clinical data on pain or symptom burden in patients with COPD, or pain as a domain of quality of life (QoL). All types of study designs were included.

resultsOf the 1571 articles that were identified, 39 met the inclusion criteria and were included in this review. Fourteen studies focused on pain and symptom burden (including pain) in patients with COPD and 25 studies focused on QoL using a questionnaire that included a separate pain domain. Reported pain prevalence in high-quality studies ranged from 32 to 60%. Included studies report that pain is more prevalent in patients with COPD compared to participants from the general population. Comorbidity, nutritional status, QoL and several symptoms were related to pain. None of the included studies reported a significant relationship between lung function and pain prevalence or severity. However, studies investigating pain in patients with moderate COPD reported higher pain prevalence compared to studies in patients with severe of very severe COPD.

conclusionsAlthough literature on this topic is limited and shows substantial heterogeneity, pain seems to be a significant problem in patients with COPD and is related to several other symptoms, comorbidity and QoL. Data synthesis suggests that pain is more prevalent in patients with moderate COPD compared to patients with severe or very severe COPD. Further research is needed and should focus on determining a more accurate pain prevalence, investigating the relationship between pain prevalence, disease severity and comorbidity and explore implementation and efficacy of pain management interventions in patients with COPD.

Indexed as

HumansPainPain ManagementPrevalencePulmonary Disease, Chronic ObstructivePAIN MANAGEMENTPRIMARY CARERESPIRATORY MEDICINE (see Thoracic Medicine)

Identifiers

PMID25260370
PMCPMC4179414
OpenAlexW2136600179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.