ArticleEuropean journal of applied physiology2015
Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls.
Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effects of concurrent aerobic and resistance training on vascular health in type 2 diabetes: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis.Cardiovascular diabetology · 2018Pooled it
- Effects of pioglitazone with and without exercise training on cardiorespiratory fitness and oxygen uptake kinetics in type 2 diabetes.Diabetes, obesity & metabolism · 2025Trial
- Cocoa-flavanols enhance moderate-intensity pulmonaryEuropean journal of applied physiology · 2021Trial
- Can exercise training enhance the repeated remote ischaemic preconditioning stimulus on peripheral and cerebrovascular function in high-risk individuals?European journal of applied physiology · 2021Trial
- Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults.Journal of human hypertension · 2016Trial
- Exercise training improves cardiorespiratory fitness and oxygen uptake kinetics to a similar extent in early and late middle-aged adults with type 2 diabetes.Physiological reports · 2026Article
- Article
- Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus.Scientific reports · 2025Article
- Efficacy of exercise and electromagnetic field therapy on cardiovascular disease risk in patients with type 2 diabetes mellitus. Randomized controlled trial.American journal of cardiovascular disease · 2025Article
- Article
- Effects of Exercise Interventions on Estimated Pulse Wave Velocity and Mean Arterial Pressure in Overweight Adults: The Role of Modality.Reviews in cardiovascular medicine · 2024Article
- The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus.Frontiers in physiology · 2024Review
- Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study.BMJ open diabetes research & care · 2020Article
- Improvements in fitness are not obligatory for exercise training-induced improvements in CV risk factors.Physiological reports · 2018Article
- The effects of exercise on vascular endothelial function in type 2 diabetes: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2018Review
- Aerobic exercise improves measures of vascular health in diabetic peripheral neuropathy.The International journal of neuroscience · 2017Article
- Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExercise training in healthy volunteers rapidly improves vascular function, preceding structural remodelling. No study examined the time-course of such adaptations in subjects with a priori endothelial dysfunction.
methodsWe examined brachial artery endothelial and smooth muscle function using flow-mediated dilation (FMD) and glyceryl trinitrate (GTN) administration in 13 type 2 diabetes patients (59 ± 6 years) and 10 healthy subjects (58 ± 7 years) before, during (2-weekly) and after an 8-week training programme. Arterial structure was assessed via peak blood flow and artery diameter.
resultsTraining increased peak oxygen uptake (P = 0.03), comparable between groups (P = 0.276). We observed a similar impact of training on brachial artery vasomotor function across the training period in diabetes patients and controls (FMD/GTN-ratio), with a higher FMD/GTN-ratio at 2, 6 and 8 weeks (P = 0.036). Artery diameter, peak blood flow or peak diameter had not changed after training.
conclusionTraining leads to rapid improvement in brachial artery vascular function in diabetes patients and controls. In contrast to previous observations in healthy young subjects, the increase in function was preserved after 8 weeks of training in middle-aged diabetes patients and controls, suggesting a different time-course in vascular adaptations in subjects with endothelial dysfunction.
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