Evidence map›Paper›PMID 25258664›Full record

ReviewWorld journal of stem cells2014

Training stem cells for treatment of malignant brain tumors.

Shengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Hong Zhen Yin, Brent A Dethlefs, Jiang F Zhong, John H Weiss, William G Loudon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of stem cells, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shengwen Calvin LiShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Mustafa H KabeerShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Long T VuShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Vic KeschrumrusShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Hong Zhen YinShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Brent A DethlefsShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
Jiang F ZhongShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
John H WeissShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.
William G LoudonShengwen Calvin Li, Mustafa H Kabeer, Long T Vu, Vic Keschrumrus, Brent A Dethlefs, William G Loudon, Neuro-Oncology and Stem Cell Research Laboratory, Center for Neuroscience Research, Children's Hospital of Orange County, University of California-Irvine, Orange, CA 92868, United States.

Funding

Multi-phase Microfluidic Devices for Characterization of Circulating Tumor CellsR01CA164509 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHONG, JOHN · 2012 to 2016
$2.0M
NCI NIH HHS R01 CA164509
6 · The paper itself

Abstract

The treatment of malignant brain tumors remains a challenge. Stem cell technology has been applied in the treatment of brain tumors largely because of the ability of some stem cells to infiltrate into regions within the brain where tumor cells migrate as shown in preclinical studies. However, not all of these efforts can translate in the effective treatment that improves the quality of life for patients. Here, we perform a literature review to identify the problems in the field. Given the lack of efficacy of most stem cell-based agents used in the treatment of malignant brain tumors, we found that stem cell distribution (i.e., only a fraction of stem cells applied capable of targeting tumors) are among the limiting factors. We provide guidelines for potential improvements in stem cell distribution. Specifically, we use an engineered tissue graft platform that replicates the in vivo microenvironment, and provide our data to validate that this culture platform is viable for producing stem cells that have better stem cell distribution than with the Petri dish culture system.

Indexed as

Engineered tissue graftMalignant brain tumorsOrganotypic slice modelStem cells

Identifiers

PMID25258664
PMCPMC4172671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.