Evidence map›Paper›PMID 25258543›Full record

ArticleOncoTargets and therapy2014

Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer.

Jian Ding, Dan Li, Minzhen Gong, Jinpo Wang, Xunru Huang, Ting Wu, Chengdang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Jian DingDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Dan LiDigestive Department of Union Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Minzhen GongDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Jinpo WangDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Xunru HuangDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Ting WuDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Chengdang WangDigestive Department of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Union Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHighly sensitive markers are urgently needed for the diagnosis and grading of gastric cancer and for managing drug resistance. The recent identification of long-non-coding RNAs (lncRNAs) has provided new approaches for resolving this challenge. The aim of this study was to screen and identify new biomarkers for human gastric cancer from lncRNAs.

methodsFirst, we used lncRNA microarrays to conduct a preliminary screening for candidate lncRNAs of gastric cancer biomarkers in both human gastric cancer tissues and in two gastric cancer cell lines, SGC7901 cells and paclitaxel-resistant SGC7901 cells. The lncRNA plasma-cytoma variant translocation 1 (PVT1) was found to exhibit higher expression in both gastric cancer tissues and the SGC7901 paclitaxel-resistant cell line. Quantitative polymerase chain reaction was used for large-scale analysis in a large number of human gastric cancer tissues to verify the involvement of PVT1 in development of gastric cancer. The relationships between PVT1 expression and clinical features were also analyzed.

resultsPVT1 showed higher expression in human gastric cancer tissues than in adjacent non-cancerous tissues and in SGC7901 paclitaxel-resistant cells compared with SGC7901 cells. PVT1 expression was correlated with lymph node invasion of gastric cancer.

conclusionPVT1 is a new biomarker for human gastric cancer and may indicate lymph node invasion. Therefore, PVT1 shows potential as a novel therapeutic target for the treatment of gastric cancer and enhancement of paclitaxel sensitivity.

Indexed as

lymph node invasionmicroarray analysispaclitaxel resistancequantitative polymerase chain reactiontumor biomarkers

Identifiers

PMID25258543
PMCPMC4172193
OpenAlexW1964713316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.