SynthesisLasers in medical science2015
Low-level laser therapy for orthodontic pain: a systematic review.
Synthesis in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Umbrella review of low-level light therapy: evidence across clinical conditions.Lasers in medical science · 2026Pooled it
- Effect of photobiomodulation therapy on mini-implant stability: a systematic review and meta-analysis.Lasers in medical science · 2021Pooled it
- Low-level laser therapy for carpal tunnel syndrome.The Cochrane database of systematic reviews · 2017Pooled it
- Efficacy of low-level laser therapy in accelerating tooth movement, preventing relapse and managing acute pain during orthodontic treatment in humans: a systematic review.BMC oral health · 2016Pooled it
- The effectiveness of low-level diode laser therapy on orthodontic pain management: a systematic review and meta-analysis.Lasers in medical science · 2015Pooled it
- Postoperative pain after emergency pulpectomy with or without photobiomodulation in symptomatic irreversible pulpitis A randomized clinical trial.Scientific reports · 2026Trial
- Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial.Dental press journal of orthodontics · 2026Trial
- Effect of 850 nm LED irradiation on the alignment of crowded mandibular anterior teeth: a randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Low-level laser therapy and laser acupuncture therapy for pain relief after initial archwire placement : A randomized clinical trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2024Trial
- The effectiveness of low-level laser therapy and low-intensity pulsed ultrasound in reducing pain induced by orthodontic separation: a randomized controlled trial.BMC oral health · 2024Trial
- Low-level laser therapy effectiveness in reducing initial orthodontic archwire placement pain in premolars extraction cases: a single-blind, placebo-controlled, randomized clinical trial.BMC oral health · 2020Trial
- Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study.Lasers in medical science · 2020Trial
- Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch-a randomized clinical controlled trial.Lasers in medical science · 2020Trial
- Photobiomodulation and Pain Reduction in Patients Requiring Orthodontic Band Application: Randomized Clinical Trial.BioMed research international · 2020Trial
- Low-level laser therapy (830 nm) on orthodontic pain: blinded randomized clinical trial.Lasers in medical science · 2019Trial
- Effect of photobiomodulation therapy on postoperative pain after endodontic treatment: a randomized, controlled, clinical study.Clinical oral investigations · 2019Trial
- Effect of low-level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment.International journal of oral science · 2018Trial
- Effect of led photobiomodulation on analgesia during labor: Study protocol for a randomized clinical trial.Medicine · 2018Trial
- Evaluation of the use of low-level laser therapy in pain control in orthodontic patients: A randomized split-mouth clinical trial.The Angle orthodontist · 2016Trial
- Effect of single-dose low-level helium-neon laser irradiation on orthodontic pain: a split-mouth single-blind placebo-controlled randomized clinical trial.Progress in orthodontics · 2015Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aimed to evaluate the clinical outcome of different lasers management on orthodontic pain. Cochrane Library (Issue 7, 2014) and MEDLINE (1966-2014.7) were searched to collect randomized controlled trials on lasers for orthodontic pain. Studies meeting the inclusion criteria were systematically evaluated. The Cochrane Collaboration tools RevMan5.1.7 and GRADEpro 3.6 were used in this systematic review and meta-analysis. As a result, 11 randomized controlled trials (RCTs) studying on low-level laser therapy (LLLT) for orthodontic pain control were included. Meta-analysis and risk of bias assessment were implemented using RevMan5.1.7, and level of evidence assessments was measured by GRADEpro 3.6. In the outcome of the score of the most painful day, the comparison of laser versus placebo (pain associated with tooth movement) demonstrated that LLLT reduced the pain score significantly compared with placebo groups (MD = -4.39, 95% CI range -5.9--2.88, P < 0.00001). In the same way, the most painful day was significantly brought forward in laser versus control group (MD = -0.42, 95% CI range -0.74--0.10, P = 0.009). Furthermore, the outcome of the end of pain day showed a trend of pain termination earlier in laser versus control and placebo groups, but without statistical significance (MD = -1.37, 95% CI range -3.37-0.64, P = 0.18 and MD = -1.04, 95% CI range -4.22-2.15, P = 0.52). However, for the reason of downgrade factors, all the GRADE level of evidences of eight comparisons for three outcomes showed a very low quality. Therefore, for the methodological shortcomings and risk of bias of RCTs included, insufficient evidence was submitted to judge whether LLLT was effective in relieving orthodontic pain. Further and more perfect researches should be done in order to recommend LLLT as a routine method for orthodontic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.