ArticleScience (New York, N.Y.)2014
Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers.
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Who cites it
158 citing papers in PubMed, 403 citations in OpenAlex.
- Redox-state-dependent CO binding in MoFe nitrogenase: insights from EPR, IR, and QM/MM analysis.Chemical science · 2026Article
- Molecular basis of NNature communications · 2026Article
- Molybdenum doping enhances backbonding at neighboring iron centers in iron-sulfur clusters.Chem · 2026Article
- A Proposed Complete-Cycle Mechanism for Conversion of NChembiochem : a European journal of chemical biology · 2026Article
- Reversible NNational science review · 2026Article
- Recasting Nitrogenase's Carbide Role as a Beating Heart of Steel: A Joint Inorganic and Organic Perspective for μInorganic chemistry · 2026Article
- Simulating Metal Complex Formation and Ligand Exchange: Unraveling the Interplay between Entropy, Kinetics, and Mechanisms on the Chelate Effect.Journal of chemical theory and computation · 2025Article
- Catalytic and stoichiometric stepwise conversion of side-on bound dinitrogen to ammonia mediated by a uranium complex.Nature chemistry · 2025Article
- Belt-Sulfur Mobilization as a Crucial Mechanistic Feature Shared between the Vanadium and Molybdenum Nitrogenases.Chem catalysis · 2025Article
- Synthetic models of the nitrogenase FeMo cofactor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Diiron(I/II) μ-1,2-Carbonyl Complex Relevant to CO Binding on Fe(111).Inorganic chemistry · 2025Article
- Molybdenum-Catalyzed Ammonia Synthesis by Using Zero-Valent Metal Powder with Alcohols or Water.Angewandte Chemie (International ed. in English) · 2025Article
- Molybdenum-Iron-Sulfur Cluster with a Bridging Carbide Ligand as a Partial FeMoco Model: CO Activation, EPR Studies, and Bonding Insight.Journal of the American Chemical Society · 2025Article
- The nitrogenase mechanism: new roles for the dangler?Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Review
- Article
- Investigating the Molybdenum Nitrogenase Mechanistic Cycle Using Spectroelectrochemistry.Journal of the American Chemical Society · 2025Article
- Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage.Nature catalysis · 2025Article
- Structural evolution of nitrogenase states under alkaline turnover.Nature communications · 2024Article
- Bridging Carbonyl and Carbyne Complexes of Weak-Field Iron: Electronic Structure and Iron-Carbon Bonding.Journal of the American Chemical Society · 2024Article
- Reaction Mechanism for CO Reduction by Mo-Nitrogenase Studied by QM/MM.Inorganic chemistry · 2024Article
98 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The mechanism of nitrogenase remains enigmatic, with a major unresolved issue concerning how inhibitors and substrates bind to the active site. We report a crystal structure of carbon monoxide (CO)-inhibited nitrogenase molybdenum-iron (MoFe)-protein at 1.50 angstrom resolution, which reveals a CO molecule bridging Fe2 and Fe6 of the FeMo-cofactor. The μ2 binding geometry is achieved by replacing a belt-sulfur atom (S2B) and highlights the generation of a reactive iron species uncovered by the displacement of sulfur. The CO inhibition is fully reversible as established by regain of enzyme activity and reappearance of S2B in the 1.43 angstrom resolution structure of the reactivated enzyme. The substantial and reversible reorganization of the FeMo-cofactor accompanying CO binding was unanticipated and provides insights into a catalytically competent state of nitrogenase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.