ReviewMetabolites2014
Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches.
Review in Metabolites, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of exercise followed by a low-carbohydrate diet on peak fat oxidation and mitochondrial coupling control and efficiency in healthy trained men.The Journal of physiology · 2026Trial
- Association of Acylcarnitine Species and Anthropometry Markers in a Population-Based Apparently Healthy Cohort.Metabolites · 2026Article
- Time-Resolved Metabolomics Reveals Mitochondrial Protection in Septic Liver Injury.Metabolites · 2025Article
- NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke.Metabolic brain disease · 2024Article
- Nitro-Deficient Niclosamide Confers Reduced Genotoxicity and Retains Mitochondrial Uncoupling Activity for Cancer Therapy.International journal of molecular sciences · 2021Article
- Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study.Metabolites · 2021Article
- Plant Mitochondrial Carriers: Molecular Gatekeepers That Help to Regulate Plant Central Carbon Metabolism.Plants (Basel, Switzerland) · 2020Review
- Jasmonic Acid Signaling Pathway in Response to Abiotic Stresses in Plants.International journal of molecular sciences · 2020Review
- Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Diagnosis, management, and follow-up of mitochondrial disorders in childhood: a personalized medicine in the new era of genome sequence.European journal of pediatrics · 2019Review
- Glucose and glutamine handling in the Sertoli cells of transgenic rats overexpressing regucalcin: plasticity towards lactate production.Scientific reports · 2018Article
- Observation of acetyl phosphate formation in mammalian mitochondria using real-time in-organelle NMR metabolomics.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats viaBMC complementary and alternative medicine · 2017Article
- Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently.Oxidative medicine and cellular longevity · 2017Article
- Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: A population study.PloS one · 2017Article
- Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency.International journal of molecular sciences · 2016Article
- Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children.Journal of diabetes research · 2016Article
- A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh SyndromeCell reports · 2015Article
- Multi-omic signature of body weight change: results from a population-based cohort study.BMC medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial dysfunction(s) (MDs) can be defined as alterations in the mitochondria, including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the mitochondrial respiratory chain, mitochondrial network fragmentation, mitochondrial or nuclear DNA mutations and the mitochondrial accumulation of protein aggregates. All these MDs are known to alter the capacity of ATP production and are observed in several pathological states/diseases, including cancer, obesity, muscle and neurological disorders. The induction of MDs can also alter the secretion of several metabolites, reactive oxygen species production and modify several cell-signalling pathways to resolve the mitochondrial dysfunction or ultimately trigger cell death. Many metabolites, such as fatty acids and derived compounds, could be secreted into the blood stream by cells suffering from mitochondrial alterations. In this review, we summarize how a mitochondrial uncoupling can modify metabolites, the signalling pathways and transcription factors involved in this process. We describe how to identify the causes or consequences of mitochondrial dysfunction using metabolomics (liquid and gas chromatography associated with mass spectrometry analysis, NMR spectroscopy) in the obesity and insulin resistance thematic.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.