Evidence map›Paper›PMID 25257990›Full record

ArticleLeukemia2015

The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice.

T R Rosean, V S Tompkins, A K Olivier, R Sompallae, L A Norian, H C Morse, T J Waldschmidt, S Janz

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Bioactive Compounds fromOncoTargets and therapy · 2020
    Article
  4. Review
  5. Transgenic mouse model of IgMBlood cancer journal · 2016
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T R RoseanInterdisciplinary Graduate Program in Immunology, University of Iowa (UI), Iowa City, IA, USA.
V S TompkinsDepartment of Pathology, UI Carver College of Medicine, Iowa City, IA, USA.
A K OlivierDepartment of Pathology, UI Carver College of Medicine, Iowa City, IA, USA.
R Sompallae1] Department of Pathology, UI Carver College of Medicine, Iowa City, IA, USA [2] Bioinformatics Core Facility, UI Carver College of Medicine, Iowa City, IA, USA.
L A Norian1] Interdisciplinary Graduate Program in Immunology, University of Iowa (UI), Iowa City, IA, USA [2] Department of Urology, UI Carver College of Medicine, Iowa City, IA, USA.
H C MorseLaboratory of Immunogenetics, NIAID, NIH, Rockville, MD, USA.
T J Waldschmidt1] Interdisciplinary Graduate Program in Immunology, University of Iowa (UI), Iowa City, IA, USA [2] Department of Pathology, UI Carver College of Medicine, Iowa City, IA, USA.
S Janz1] Interdisciplinary Graduate Program in Immunology, University of Iowa (UI), Iowa City, IA, USA [2] Department of Pathology, UI Carver College of Medicine, Iowa City, IA, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Molecular Regulation of B-Cell Differentiation and FunctionZIAAI001024 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MORSE, HERBERT · 2009 to 2018
$8.3M
PROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5M
PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Lymphomas And Retroviral PathogenesisZIAAI000858 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MORSE, HERBERT · 2009 to 2018
$5.3M
Defining genetic pathways of plasma-cell neoplasiaR01CA151354 · NCI · UNIVERSITY OF IOWA · PI JANZ, SIEGFRIED · 2010 to 2022
$3.9M
NCI NIH HHS P30 CA086862NCI NIH HHS P30CA086862NCI NIH HHS P50 CA097274NCI NIH HHS P50CA097274NCI NIH HHS R01 CA151354NCI NIH HHS R01CA151354NHLBI NIH HHS T32 HL007344NIAID NIH HHS 5T32 AI007485NIAID NIH HHS T32 AI007485
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Tumor MicroenvironmentAnimalsInterleukin-6MicePlasmacytomaInterleukin-6

Identifiers

PMID25257990
PMCPMC4286499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.