ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015
Comparison of puff topography, toxicant exposure, and subjective effects in low- and high-frequency waterpipe users: a double-blind, placebo-control study.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effect of graphic warning label on acute changes in waterpipe tobacco smoking behavior, biomarkers of exposure and harm, and subjective effects in a randomized trial.Addictive behaviors · 2026Trial
- Waterpipe Size Matters: The Effect of Waterpipe Size on Toxicant Exposures and Subjective Experiences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Initial evidence of the acute effect of electronic nicotine delivery system use on energy intake.Experimental and clinical psychopharmacology · 2024Trial
- Acute effects of snus in never-tobacco users: a pilot study.The American journal of drug and alcohol abuse · 2018Trial
- Emissions from conventional and electronic waterpipes relative to cigarettes and a heated tobacco product.Scientific reports · 2025Article
- Trends and Disparities in Waterpipe Tobacco Smoking Among US Adolescents and Adults: PATH Study 2013-2021.Tobacco use insights · 2024Article
- Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men.Substance abuse : research and treatment · 2023Article
- Comparative Genotoxicity and Mutagenicity of Cigarette, Cigarillo, and Shisha Tobacco Products in Epithelial and Cardiac Cells.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Comparison of Measurement Methods for Electronic Cigarette Puff Topography.Tobacco regulatory science · 2020Article
- Puffing topography and physiological responses in men and women with low versus high waterpipe dependence during smoking: The WiHi Irbid project.Drug and alcohol dependence · 2020Article
- A Procedure to Standardize Puff Topography During Evaluations of Acute Tobacco or Electronic Cigarette Exposure.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Comparison of cigarette, little cigar, and waterpipe tobacco smoke condensate and e-cigarette aerosol condensate in a self-administration model.Behavioural brain research · 2019Article
- The effects of hookah/waterpipe smoking on general health and the cardiovascular system.Environmental health and preventive medicine · 2019Review
- Differences in puff topography, toxicant exposure, and subjective response between waterpipe tobacco smoking men and women.Experimental and clinical psychopharmacology · 2018Article
- Comparison of toxicant load from waterpipe and cigarette tobacco smoking among young adults in the USA.Tobacco control · 2018Article
- Comparison of a preferred versus non-preferred waterpipe tobacco flavour: subjective experience, smoking behaviour and toxicant exposure.Tobacco control · 2018Article
- Expanding clinical laboratory tobacco product evaluation methods to loose-leaf tobacco vaporizers.Drug and alcohol dependence · 2016Article
- Group Waterpipe Tobacco Smoking Increases Smoke Toxicant Concentration.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Waterpipe Tobacco Use in the United Kingdom: A Cross-Sectional Study among University Students and Stop Smoking Practitioners.PloS one · 2016Article
- Waterpipe tobacco smoking: A new smoking epidemic among the young?Current pulmonology reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionClinical laboratory work among intermittent and daily waterpipe tobacco smokers has revealed significant risks for tobacco dependence and disease associated with waterpipe tobacco smoking (WTS). No studies have compared these groups directly. This study examined whether WTS frequency was associated with differential puff topography, toxicant exposure, and subjective response using a placebo-control design.
methodsEighty participants reporting WTS of 2-5 episodes (LOW; n = 63) or ≥20 episodes (HIGH; n = 17) per month for ≥6 months completed 2 double-blind, counterbalanced 2-hr sessions that were preceded by ≥12hr of tobacco abstinence. Sessions differed by product smoked ad libitum for 45+ min: preferred brand/flavor of waterpipe tobacco (active) or a flavor-matched tobacco-free waterpipe product (placebo). Outcomes included puff topography, plasma nicotine, carboxyhemoglobin (COHb), and subjective response.
resultsHIGH users had more puffs, shorter inter-puff-intervals, and a higher total puff volume for placebo relative to active, as well as relative to LOW users during placebo. Plasma nicotine concentrations increased when smoking active (but not placebo) with no significant differences between groups at 25min post-product administration. COHb increased significantly during all conditions; the largest increase was for HIGH users when smoking placebo. There was some evidence of higher baseline scores for nicotine/tobacco nicotine abstinence symptomology.
conclusionsHigher frequency waterpipe users may be more sensitive to the effects of waterpipe smoke nicotine content. Among HIGH users, higher baseline nicotine/tobacco abstinence symptoms may indicate greater nicotine dependence. These data support continued surveillance of WTS and development of dependence measures specific to this product.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.