Evidence map›Paper›PMID 25257978›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015

A test of the stress-buffering model of social support in smoking cessation: is the relationship between social support and time to relapse mediated by reduced withdrawal symptoms?

Kasey G Creswell, Yu Cheng, Michele D Levine

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Trial
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  6. Article
  7. Article
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  10. A longitudinal study of the association between the teachable moment heuristic and smoking of head and neck cancer patients.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Death anxiety among caregivers of patients with advanced cancer: a cross-sectional survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  15. Article
  16. Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kasey G CreswellDepartment of Psychology, Carnegie Mellon University, Pittsburgh, PA; kasey@andrew.cmu.edu.
Yu ChengDepartment of Statistics, University of Pittsburgh, Pittsburgh, PA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
Michele D LevineDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA.

Funding

Addressing Postpartum Mood and Weight Concerns to Sustain Smoking CessationR01DA021608 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, MICHELE D · 2007 to 2011
$2.6M
NICOTINE, ENERGY BALANCE, AND PREVENTION OF WEIGHT GAINR01DA004174 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARCUS, MARSHA D · 1986 to 2004
$1.5M
NIDA NIH HHS R01 DA004174NIDA NIH HHS R01 DA021608NIDA NIH HHS R01 DA04174
6 · The paper itself

Abstract

introductionSocial support has been linked to quitting smoking, but the mechanisms by which social support affects cessation are poorly understood. The current study tested a stress-buffering model of social support, which posits that social support protects or "buffers" individuals from stress related to quitting smoking. We hypothesized that social support would be negatively associated with risk of relapse, and that this effect would be mediated by reduced withdrawal and depressive symptoms (i.e., cessation-related stress) over time. Further, we predicted that trait neuroticism would moderate this mediational effect, such that individuals high in negative affectivity would show the greatest stress-buffering effects of social support.

methodsParticipants were weight-concerned women (n = 349) ages 18-65 enrolled in a randomized, double-blind, placebo-controlled smoking cessation trial of bupropion and cognitive behavioral therapy. Social support was assessed at baseline, and biochemically-verified abstinence, withdrawal-related symptoms, and depressive symptoms were assessed at 1-, 3-, 6-, and 12-months follow-up.

resultsSocial support was negatively related to risk of relapse in survival models and negatively related to withdrawal symptoms and depression in mixed effects models. These relationships held after controlling for the effects of pre-quit day negative affect and depression symptoms, assignment to treatment condition, and number of cigarettes smoked per day. A temporal mediation model showed that the effect of social support on risk of relapse was mediated by reductions in withdrawal symptoms over time but not by depression over time. Contrary to hypotheses, we did not find that neuroticism moderated this mediation effect.

conclusionsIncreased social support may buffer women from the harmful effects of cessation-related withdrawal symptoms, which in turn improve cessation outcomes.

Indexed as

Social SupportStress, PsychologicalAdolescentAdultAgedBupropionChronic DiseaseCognitive Behavioral TherapyCounselingDepressionDouble-Blind MethodFemaleHumansMiddle AgedRecurrenceSmokingBupropion

Identifiers

PMID25257978
PMCPMC4498137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.