Evidence map›Paper›PMID 25257882›Full record

ReviewInternational journal of oral science2014

Probiotics to counteract biofilm-associated infections: promising and conflicting data.

Claudia Vuotto, Francesca Longo, Gianfranco Donelli

Open access · goldAbstract readReview
In one paragraph

Review in International journal of oral science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comparative phase I randomized open-label pilot clinical trial of GynophilusEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Trial
  4. Review
  5. Evaluation of antimicrobial efficacy of two commercially available probiotics againstJournal of conservative dentistry and endodontics · 2026
    Article
  6. Effects of Oral Probiotics onDentistry journal · 2026
    Review
  7. Antibacterial and antibiofilm effects of synbiotics against multidrug-resistant bacteria: Acinetobacter baumannii and Enterococcus faecalis.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  8. Review
  9. ExploringmicroLife · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Strategic antagonism: howFrontiers in microbiology · 2025
    Review
  16. Article
  17. Review
  18. Impact ofNutrients · 2024
    Article
  19. Article
  20. Enterococcus mundtii A2 biofilm and its anti-adherence potential against pathogenic microorganisms on stainless steel 316L.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claudia Vuotto
Francesca Longo
Gianfranco Donelli
Fondazione Santa Lucia · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Altered bowel flora is currently thought to play a role in a variety of disease conditions, and the use of Bifidobacterium spp. and Lactobacillus spp. as probiotics has been demonstrated to be health-promoting, even if the success of their administration depends on the applied bacterial strain(s) and the targeted disease. In the last few decades, specific probiotics have been shown to be effective in the treatment or the prevention of acute viral gastroenteritis, pediatric post-antibiotic-associated diarrhea, some pediatric allergic disorders, necrotizing enterocolitis in preterm infants, inflammatory bowel diseases and postsurgical pouchitis. The potential application of probiotics is continuously widening, with new evidence accumulating to support their effect on the prevention and treatment of other disease conditions, including several oral diseases, such as dental caries, periodontal diseases and oral malodor, as well as genitourinary and wound infections. Considering the increasingly widespread ability of pathogens to generate persistent biofilm-related infections, an even more attractive proposal is to administer probiotics to prevent or counteract biofilm development. The response of biofilm-based oral, intestinal, vaginal and wound infections to probiotics treatment will be reviewed here in light of the most recent results obtained in this field.

Indexed as

BiofilmsAntibiosisBacterial InfectionsBifidobacteriumHumansLactobacillusMucous MembraneProbiotics

Identifiers

PMID25257882
PMCPMC5153589
OpenAlexW2057213586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.