ReviewParasitology2015
Large, rapidly evolving gene families are at the forefront of host-parasite interactions in Apicomplexa.
Review in Parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What helminth genomes have taught us about parasite evolution.Parasitology · 2015Pooled it
- De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription.BMC genomics · 2025Article
- A Study of Cross-Protection betweenPathogens (Basel, Switzerland) · 2024Article
- The Hypervariable Tpr Multigene Family of Theileria Parasites, Defined by a Conserved, Membrane-Associated, C-Terminal Domain, Includes Several Copies with Defined Orthology Between Species.Journal of molecular evolution · 2023Article
- High transmission efficiency of the simian malaria vectors and population expansion of their parasites Plasmodium cynomolgi and Plasmodium inui.PLoS neglected tropical diseases · 2023Article
- Mobilome of Apicomplexa Parasites.Genes · 2022Article
- Varia: a tool for prediction, analysis and visualisation of variable genes.BMC bioinformatics · 2022Article
- Contrasting drivers of diversity in hosts and parasites across the tropical Andes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys.PLoS pathogens · 2020Article
- Comparative genomic analysis of three intestinal species reveals reductions in secreted pathogenesis determinants in bovine-specific and non-pathogenicMicrobial genomics · 2020Article
- Re-annotation of the Theileria parva genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved pathway in many organisms.BMC genomics · 2020Article
- A single-parasite transcriptional atlas ofeLife · 2020Article
- Host-Malaria Parasite Interactions and Impacts on Mutual Evolution.Frontiers in cellular and infection microbiology · 2020Review
- Comparative 3D genome organization in apicomplexan parasites.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites.Epigenetics insights · 2019Article
- The Structure of a Conserved Telomeric Region Associated with Variant Antigen Loci in the Blood Parasite Trypanosoma congolense.Genome biology and evolution · 2018Article
- Article
- Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites.Cell host & microbe · 2018Article
- Genomics of apicomplexan parasites.Critical reviews in biochemistry and molecular biology · 2017Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The Apicomplexa is a phylum of parasitic protozoa, which includes the malaria parasite Plasmodium, amongst other species that can devastate human and animal health. The past decade has seen the release of genome sequences for many of the most important apicomplexan species, providing an excellent basis for improving our understanding of their biology. One of the key features of each genome is a unique set of large, variant gene families. Although closely related species share the same families, even different types of malaria parasite have distinct families. In some species they tend to be found at the ends of chromosomes, which may facilitate aspects of gene expression regulation and generation of sequence diversity. In others they are scattered apparently randomly across chromosomes. For some families there is evidence they are involved in antigenic variation, immune regulation and immune evasion. For others there are no known functions. Even where function is unknown these families are most often predicted to be exposed to the host, contain much sequence diversity and evolve rapidly. Based on these properties it is clear that they are at the forefront of host-parasite interactions. In this review I compare and contrast the genomic context, gene structure, gene expression, protein localization and function of these families across different species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.