ReviewThe British journal of radiology2015
Future development of biologically relevant dosimetry.
Review in The British journal of radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- An ion treatment planning framework for inclusion of nanodosimetric ionization detail through cluster dose.Medical physics · 2026Article
- A computational method to estimate the relative biological effectiveness and tumor control probability for low-LET proton irradiations.PloS one · 2026Article
- Ionization Detail Parameters for DNA Damage Evaluation in Charged Particle Radiotherapy: Simulation Study Based on Cell Survival Database.International journal of molecular sciences · 2024Article
- Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.Physics in medicine and biology · 2023Article
- Repair Kinetics of DSB-Foci Induced by Proton and α-Particle Microbeams of Different Energies.Life (Basel, Switzerland) · 2022Article
- On the measurement uncertainty of microdosimetric quantities using diamond and silicon microdosimeters in carbon-ion beams.Medical physics · 2022Article
- Applications of nanodosimetry in particle therapy planning and beyond.Physics in medicine and biology · 2021Review
- Investigation into the foundations of the track-event theory of cell survival and the radiation action model based on nanodosimetry.Radiation and environmental biophysics · 2021Article
- Impact of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for a 62-MeV Therapeutic Proton Beam.Cancers · 2021Article
- EURADOS STRATEGIC RESEARCH AGENDA 2020: VISION FOR THE DOSIMETRY OF IONISING RADIATION.Radiation protection dosimetry · 2021Article
- The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions.Journal of personalized medicine · 2021Article
- Internal microdosimetry of alpha-emitting radionuclides.Radiation and environmental biophysics · 2020Review
- Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy.Physics in medicine and biology · 2018Article
- Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations.Physics in medicine and biology · 2017Article
- Track structure model of microscopic energy deposition by protons and heavy ions in segments of neuronal cell dendrites represented by cylinders or spheres.Life sciences in space research · 2017Article
- Nothing endures but change.The British journal of radiology · 2017Article
- Nanodosimetry-Based Plan Optimization for Particle Therapy.Computational and mathematical methods in medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton and ion beams are radiotherapy modalities of increasing importance and interest. Because of the different biological dose response of these radiations as compared with high-energy photon beams, the current approach of treatment prescription is based on the product of the absorbed dose to water and a biological weighting factor, but this is found to be insufficient for providing a generic method to quantify the biological outcome of radiation. It is therefore suggested to define new dosimetric quantities that allow a transparent separation of the physical processes from the biological ones. Given the complexity of the initiation and occurrence of biological processes on various time and length scales, and given that neither microdosimetry nor nanodosimetry on their own can fully describe the biological effects as a function of the distribution of energy deposition or ionization, a multiscale approach is needed to lay the foundation for the aforementioned new physical quantities relating track structure to relative biological effectiveness in proton and ion beam therapy. This article reviews the state-of-the-art microdosimetry, nanodosimetry, track structure simulations, quantification of reactive species, reference radiobiological data, cross-section data and multiscale models of biological response in the context of realizing the new quantities. It also introduces the European metrology project, Biologically Weighted Quantities in Radiotherapy, which aims to investigate the feasibility of establishing a multiscale model as the basis of the new quantities. A tentative generic expression of how the weighting of physical quantities at different length scales could be carried out is presented.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.