Evidence map›Paper›PMID 25257652›Full record

ArticleParasitology2015

Variation and covariation in strongyle infection in East African shorthorn zebu calves.

R Callaby, O Hanotte, I Conradie Van Wyk, H Kiara, P Toye, M N Mbole-Kariuki, A Jennings, S M Thumbi, J A W Coetzer, B M de C Bronsvoort and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

R CallabyInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories,Kings Buildings, West Mains Road, Edinburgh EH9 3JT,UK.
O HanotteSchool of Life Sciences, University of Nottingham,University Park, Nottingham NG7 2RD,UK.
I Conradie Van WykDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science,University of Pretoria,Private bag X04, Onderstepoort,South Africa.
H KiaraInternational Livestock Research Institute,P.O. Box 30709, Nairobi 00100,Kenya.
P ToyeInternational Livestock Research Institute,P.O. Box 30709, Nairobi 00100,Kenya.
M N Mbole-KariukiAfrican Union - Interafrican Bureau for Animal Resources (AU-IBAR),Kenindia Business Park building, Museum Hill, Westlands Road, P.O Box 30786, 00100 Nairobi,Kenya.
A JenningsThe Farm Animal Practice, The University of Edinburgh,Easter Bush, Edinburgh EH25 9RG,UK.
S M ThumbiCentre for Immunity, Infection and Evolution, University of Edinburgh, Ashworth Laboratories,Kings Buildings, West Mains Road, Edinburgh EH9 3JT,UK.
J A W CoetzerDepartment of Veterinary Tropical Diseases, Faculty of Veterinary Science,University of Pretoria,Private bag X04, Onderstepoort,South Africa.
B M de C BronsvoortThe Roslin Institute, Easter Bush, University of Edinburgh,Roslin, Midlothian EH25 9RG,UK.
S A KnottInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories,Kings Buildings, West Mains Road, Edinburgh EH9 3JT,UK.
M E J WoolhouseInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories,Kings Buildings, West Mains Road, Edinburgh EH9 3JT,UK.
L E B KruukDivision of Evolution, Ecology & Genetics,Research School of Biology, The Australian National University,Canberra, ACT 0200,Australia.
University of Edinburgh · GBCentre for Immunity, Infection and Evolution · GBInternational Livestock Research Institute · KEUniversity of Pretoria · ZAAfrican Union Interafrican Bureau for Animal Resources · KEUniversity of Nottingham · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20211554Wellcome TrustWellcome Trust 079445
6 · The paper itself

Abstract

Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a cohort of indigenous zebu calves in Western Kenya, using relatedness matrices reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h(2) = 23.9%, s.e. = 11.8%) and we also found heritability of white blood cell counts (WBC) (h(2) = 27.6%, s.e. = 10.6%). All the traits investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count. Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16-51 weeks, with smaller calves having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and also reveal consistently strong negative associations between strongyle infection and other important aspects of the multivariate phenotype.

Indexed as

AnimalsBirth WeightBlood ProteinsCattleCattle DiseasesCluster AnalysisErythrocyte CountFecesGenotypeKenyaLeukocyte CountParasite Egg CountPolymorphism, Single NucleotideStrongylida InfectionsStrongylusWeight GainBlood Proteinshaematology

Identifiers

PMID25257652
PMCPMC5844460
OpenAlexW2162532926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.