ArticleBiochimica et biophysica acta2014
Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Dental Pulp-Derived Stem Cells Preserve Astrocyte Health During Induced Gliosis by Modulating Mitochondrial Activity and Functions.Cellular and molecular neurobiology · 2023Article
- Polyphenolic Compounds Inhibit Osteoclast Differentiation While Reducing Autophagy through Limiting ROS and the Mitochondrial Membrane Potential.Biomolecules · 2022Article
- Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy.Cell death & disease · 2022Article
- Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome.Cytogenetic and genome research · 2021Review
- Evidence for premature aging in a Drosophila model of Werner syndrome.Experimental gerontology · 2019Article
- Acetylation of Werner protein at K1127 and K1117 is important for nuclear trafficking and DNA repair.DNA repair · 2019Article
- Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.DNA repair · 2018Article
- Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax - a liver transcriptomics approach.Scientific reports · 2017Article
- The decay of Redox-stress Response Capacity is a substantive characteristic of aging: Revising the redox theory of aging.Redox biology · 2017Article
- Recent Advances in Understanding Werner Syndrome.F1000Research · 2017Review
- Plasmodium falciparum Werner homologue is a nuclear protein and its biochemical activities reside in the N-terminal region.Protoplasma · 2016Article
- Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.PloS one · 2015Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autophagy compared to normal cells. While the fusion of phagosomes with lysosome is normal, WS cells contain fewer autophagy vacuoles. Cellular starvation autophagy in WS cells is restored after transfection with full length WRN. Further, siRNA mediated silencing of WRN in the normal fibroblast cell line WI-38 results in decreased autophagy and altered expression of autophagy related proteins. Thus, our observations suggest that WRN may have a role in controlling autophagy and hereby cellular maintenance.
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