ArticleAlcoholism, clinical and experimental research2014
Reduced left executive control network functional connectivity is associated with alcohol use disorders.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- The effects of nalmefene on the impulsive and reflective system in alcohol use disorder: A resting-state fMRI study.Psychopharmacology · 2022Trial
- Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state.Neuroimage. Reports · 2026Article
- Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2026Article
- Neural mechanisms underlying cognitive changes in individuals with alcohol use disorder: insights from resting-state functional magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2025Article
- Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study.Addictive behaviors reports · 2025Article
- Effects of alcohol and cannabis co-use on salience network resting state functional connectivity in individuals who drink alcohol heavily.Drug and alcohol dependence · 2025Article
- Abnormal intrahemispheric and interhemispheric dynamic functional connectivity density in male alcohol use disorder.Frontiers in psychiatry · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Interaction Effects of Sex, Age, APOE and Common Health Risk Factors on Human Brain Functions.medRxiv : the preprint server for health sciences · 2024Article
- Triple network resting-state functional connectivity patterns of alcohol heavy drinking.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Disrupted executive cerebro-cerebellar functional connectivity in alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Alterations of brain activity in patients with alcohol use disorder: a resting-state fMRI study.BMC psychiatry · 2023Article
- Graph Theoretical Analysis of Brain Structural Connectivity in Patients with Alcohol Dependence.Experimental neurobiology · 2023Article
- Reduced connectivity of the cognitive control neural network at rest in young adults who had their first drink of alcohol prior to age 18.Psychiatry research. Neuroimaging · 2023Article
- Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls.Frontiers in psychiatry · 2023Article
- Adolescent alcohol use is linked to disruptions in age-appropriate cortical thinning: an unsupervised machine learning approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAltered functional connectivity in critical networks has been associated with chronic alcohol abuse. In turn, changes in connectivity in executive control networks (ECNs) may undermine the ability to control alcohol consumption. It was hypothesized that network connectivity would be reduced in individuals with problematic alcohol use (ALC) compared with controls and that diminished network connectivity would be associated with greater failure to control drinking.
methodsResting-state functional magnetic resonance imaging was analyzed to identify 14 previously identified intrinsic connectivity networks (ICNs) using a priori regions of interest in cases ranging from binge drinkers to those with severe alcohol use disorder, as well as control subjects. Analyses tested for differences in network connectivity strength between 255 ALC cases and 87 age- and gender-matched controls. Further, structural equation analysis, using 383 ALC cases, tested whether functional connectivity strength mediated the relationship between years of regular drinking and alcohol problems.
resultsThe age- and gender-matched analysis showed that ALC had significantly lower network connectivity strength than controls in the left executive control (LECN), basal ganglia, and primary visual networks. For all ALC, LECN connectivity strength is negatively correlated with failed control and alcohol disorder severity. Edges connecting parietal regions with dorsolateral prefrontal, middle frontal, and temporal regions within the LECN drove these relationships. A positive association between years of drinking and severity of alcohol problems was mediated by reduced ECN connectivity.
conclusionsThis study reports relationships between network strength and problematic alcohol use, suggesting that chronic drinking negatively impacts brain connectivity, specifically in the LECN. Altered functional connectivity, related to chronic alcohol abuse, may contribute to the etiology of alcohol dependence and relapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.