Evidence map›Paper›PMID 25257173›Full record

ArticleCell death and differentiation2015

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

P A Lang, A Meryk, A A Pandyra, D Brenner, A Brüstle, H C Xu, K Merches, F Lang, V Khairnar, P Sharma and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Differences between Human and Mouse IgM Fc Receptor (FcµR).International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 3 countries.

P A Lang1] Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany [2] Department of Molecular Medicine II, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany.
A Meryk1] Department of Molecular Medicine II, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany [2] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
A A PandyraInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
D Brenner1] Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, UHN, 620 University Avenue Toronto, Toronto, ON, Canada M5G 2C1 [2] Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität Munich, Munich 81675, Germany.
A BrüstleCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, UHN, 620 University Avenue Toronto, Toronto, ON, Canada M5G 2C1.
H C Xu1] Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany [2] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.ORCID 0000000246744983
K Merches1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany [2] Department of Physiology I, University of Tuebingen, Gmelinstr. 5, Tuebingen 72076, Germany.
F LangDepartment of Physiology I, University of Tuebingen, Gmelinstr. 5, Tuebingen 72076, Germany.
V KhairnarInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.ORCID 0000000235847530
P SharmaInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
P FunknerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany.
M RecherPrimary Immunodeficiency Clinic, Medical Outpatient Division and Immunodeficiency Lab, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
N ShaabaniInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
G S DuncanCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, UHN, 620 University Avenue Toronto, Toronto, ON, Canada M5G 2C1.
V DuhanInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
B HomeyDepartment of Dermatology, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany.
P S OhashiCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, UHN, 620 University Avenue Toronto, Toronto, ON, Canada M5G 2C1.
D HäussingerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany.
P A KnolleInstitute of Molecular Immunology, Technische Universität Munich, Munich 81675, Germany.
N HonkeInstitute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
T W MakCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, UHN, 620 University Avenue Toronto, Toronto, ON, Canada M5G 2C1.
K S Lang1] Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, Düsseldorf 40225, Germany [2] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Duisburg-Essen · DEOntario Institute for Cancer Research · CATechnical University of Munich · DEUniversity Hospital of Basel · CHUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During virus infection and autoimmune disease, inflammatory dendritic cells (iDCs) differentiate from blood monocytes and infiltrate infected tissue. Following acute infection with hepatotropic viruses, iDCs are essential for re-stimulating virus-specific CD8(+) T cells and therefore contribute to virus control. Here we used the lymphocytic choriomeningitis virus (LCMV) model system to identify novel signals, which influence the recruitment and activation of iDCs in the liver. We observed that intrinsic expression of Toso (Faim3, FcμR) influenced the differentiation and activation of iDCs in vivo and DCs in vitro. Lack of iDCs in Toso-deficient (Toso(-/-)) mice reduced CD8(+) T-cell function in the liver and resulted in virus persistence. Furthermore, Toso(-/-) DCs failed to induce autoimmune diabetes in the rat insulin promoter-glycoprotein (RIP-GP) autoimmune diabetes model. In conclusion, we found that Toso has an essential role in the differentiation and maturation of iDCs, a process that is required for the control of persistence-prone virus infection.

Indexed as

AnimalsCarrier ProteinsCD8-Positive T-LymphocytesCell DifferentiationDendritic CellsDiabetes Mellitus, ExperimentalImmunity, CellularInflammationLiverLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMembrane ProteinsMiceMice, KnockoutRatsCarrier ProteinsFcmr protein, mouseMembrane Proteins

Identifiers

PMID25257173
PMCPMC4262783
OpenAlexW2078450740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.