ArticleBehavioural brain research2015
Dissociation between sickness behavior and emotionality during lipopolysaccharide challenge in lymphocyte deficient Rag2(-/-) mice.
Article in Behavioural brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Lipopolysaccharide-induced systemic inflammation alters courtship ultrasonic vocalizations in male mice.Brain, behavior, & immunity - health · 2026Article
- Article
- Targeting glycolysis for neuroprotection in early LPS-induced neuroinflammation.Brain, behavior, & immunity - health · 2024Article
- The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review.International journal of molecular sciences · 2024Review
- T cells: an emerging cast of roles in bipolar disorder.Translational psychiatry · 2023Review
- Targeting the Adaptive Immune System in Depression: Focus on T Helper 17 Cells.Pharmacological reviews · 2022Review
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Ellagic Acid Inhibits Neuroinflammation and Cognitive Impairment Induced by Lipopolysaccharides.Neurochemical research · 2020Article
- Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression.Translational psychiatry · 2020Article
- The αScientific reports · 2020Article
- T Cell Subpopulations in the Physiopathology of Fibromyalgia: Evidence and Perspectives.International journal of molecular sciences · 2020Review
- Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Neonatal adoptive transfer of lymphocytes rescues social behaviour during adolescence in immune-deficient mice.The European journal of neuroscience · 2018Article
- Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats.PloS one · 2018Article
- Expansion of brain T cells in homeostatic conditions in lymphopenic Rag2(-/-) mice.Brain, behavior, and immunity · 2016Article
- CD4(+) T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes in Rag2(-/-) mice.Stress (Amsterdam, Netherlands) · 2016Article
- CD3Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory diseases are highly associated with affective disorders including depression and anxiety. While the role of the innate immune system on emotionality has been extensively studied, the role of adaptive immunity is less understood. Considering that chronic inflammatory conditions are mediated largely by maladaptive lymphocyte function, the role of these cells on brain function and behavior during inflammation warrants investigation. In the present study we employed mice deficient in lymphocyte function and studied behavioral and inflammatory responses during challenge with bacterial lipopolysaccharides (LPS). Rag2(-/-) mice lacking mature lymphocytes were susceptible to death under sub-septic (5 mg/kg) doses of LPS and survived only to moderate (1 mg/kg) doses of LPS. Under these conditions, they displayed attenuated TNF-alpha responses and behavioral symptoms of sickness when compared with immunocompetent mice. Nevertheless, Rag2(-/-) mice had protracted motivational impairments after recovery from sickness suggesting a specific function for lymphocytes on the re-establishment of motivational states after activation of the innate immune system. The behavioral impairments in Rag2(-/-) mice were paralleled by an elevation in plasma corticosterone after behavioral tests. These results provide evidence that the absence of adaptive immunity may be associated with emotional deficits during inflammation and suggest that depressive states associated with medical illness may be mediated in part by impaired lymphocyte responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.