ArticleInvestigative ophthalmology & visual science2014
White matter consequences of retinal receptor and ganglion cell damage.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Methods of diffusion MRI tractography for localization of the anterior optic pathway: A systematic review of validated methods.NeuroImage. Clinical · 2023Pooled it
- Associations Between Myopia and Brain Volumes: An Observational and Genetic Analysis.Investigative ophthalmology & visual science · 2025Observational
- Visual Tract Integrity Before and After Gene Therapy in Congenital Achromatopsia.Translational vision science & technology · 2025Article
- Tractometry of Human Visual White Matter Pathways in Health and Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- brainlife.io: a decentralized and open-source cloud platform to support neuroscience research.Nature methods · 2024Article
- Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.Biomedicines · 2024Article
- Abnormal cerebral blood flow in patients with Leber's hereditary optic neuropathy.Brain imaging and behavior · 2023Article
- Article
- Assessing the structure of the posterior visual pathway in bilateral macular degeneration.Scientific reports · 2023Article
- Correlation between retinal structure and brain multimodal magnetic resonance imaging in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- A taxonomy of the brain's white matter: twenty-one major tracts for the 21st century.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Structural Covariance and Heritability of the Optic Tract and Primary Visual Cortex in Living Human Brains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Multishell Diffusion MR Tractography Yields Morphological and Microstructural Information of the Anterior Optic Pathway: A Proof-of-Concept Study in Patients with Leber's Hereditary Optic Neuropathy.International journal of environmental research and public health · 2022Article
- Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Multi-Contrast Magnetic Resonance Imaging of Visual White Matter Pathways in Patients With Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Brain Gray Matter Atrophy and Functional Connectivity Remodeling in Patients With Chronic LHON.Frontiers in neuroscience · 2022Article
- Neuroimaging in Leber Hereditary Optic Neuropathy: State-of-the-art and future prospects.NeuroImage. Clinical · 2022Review
- CHIASM, the human brain albinism and achiasma MRI dataset.Scientific data · 2021Article
- Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI.Human brain mapping · 2021Article
- Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system.eLife · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
purposePatients with Leber hereditary optic neuropathy (LHON) and cone-rod dystrophy (CRD) have central vision loss; but CRD damages the retinal photoreceptor layer, and LHON damages the retinal ganglion cell (RGC) layer. Using diffusion MRI, we measured how these two types of retinal damage affect the optic tract (ganglion cell axons) and optic radiation (geniculo-striate axons).
methodsAdult onset CRD (n = 5), LHON (n = 6), and healthy controls (n = 14) participated in the study. We used probabilistic fiber tractography to identify the optic tract and the optic radiation. We compared axial and radial diffusivity at many positions along the optic tract and the optic radiation.
resultsIn both types of patients, diffusion measures within the optic tract and the optic radiation differ from controls. The optic tract change is principally a decrease in axial diffusivity; the optic radiation change is principally an increase in radial diffusivity.
conclusionsBoth photoreceptor layer (CRD) and retinal ganglion cell (LHON) retinal disease causes substantial change in the visual white matter. These changes can be measured using diffusion MRI. The diffusion changes measured in the optic tract and the optic radiation differ, suggesting that they are caused by different biological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.