ArticleMicrobiologyOpen2014
The putative oligosaccharide translocase SypK connects biofilm formation with quorum signaling in Vibrio fischeri.
Article in MicrobiologyOpen, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Strain matters: host responses reflect symbiont origin in the squid-vibrio symbiosis.mSystems · 2025Article
- A single point mutation is sufficient to driveJournal of bacteriology · 2025Article
- LitR and its quorum-sensing regulators modulate biofilm formation byJournal of bacteriology · 2025Article
- Review
- Two enhancer binding proteins activate σeLife · 2023Article
- Quorum Sensing and Cyclic di-GMP Exert Control Over Motility ofFrontiers in microbiology · 2021Article
- Motility of Vibrio spp.: regulation and controlling strategies.Applied microbiology and biotechnology · 2020Review
- Investigating the short- and long-term effects of antibacterial agents using a real-time assay based on bioluminescentHeliyon · 2020Article
- Sulfur availability for Vibrio fischeri growth during symbiosis establishment depends on biogeography within the squid light organ.Molecular microbiology · 2019Article
- Tools for Rapid Genetic Engineering of Vibrio fischeri.Applied and environmental microbiology · 2018Article
- "In-Group" Communication in MarineFrontiers in cellular and infection microbiology · 2018Review
- Article
- Comparative analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2016Article
- Intraspecific Competition Impacts Vibrio fischeri Strain Diversity during Initial Colonization of the Squid Light Organ.Applied and environmental microbiology · 2016Article
- Microbial Surface Colonization and Biofilm Development in Marine Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species.Microbial pathogenesis · 2015Article
- Identification of a novel matrix protein that promotes biofilm maturation in Vibrio fischeri.Journal of bacteriology · 2015Article
- NagC represses N-acetyl-glucosamine utilization genes in Vibrio fischeri within the light organ of Euprymna scolopes.Frontiers in microbiology · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Quorum signaling (QS) describes how bacteria can use small signaling molecules (autoinducers) to coordinate group-level behaviors. In Vibrio fischeri, QS is achieved through a complex regulatory network that ultimately controls bioluminescence, motility, and host colonization. We conducted a genetic screen focused on qrr1, which encodes a small regulatory RNA that is necessary for the core quorum-signaling cascade to transduce autoinducer information into cellular responses. We isolated unique mutants with a transposon inserted into one of two genes within the syp locus, which is involved in biofilm formation. We found that overexpression of sypK, which encodes a putative oligosaccharide translocase, is sufficient to activate qrr1, and, in addition, this effect appears to depend on the kinase activity of the sensor LuxQ. Consistent with the established model for QS in V. fischeri, enhanced expression of qrr1 by the overexpression of sypK resulted in reduced bioluminescence and increased motility. Finally, we found that induction of the syp locus by overexpression of sypG was sufficient to activate qrr1 levels. Together, our results show how conditions that promote biofilm formation impact the quorum-signaling network in V. fischeri, and further highlight the integrated nature of the regulatory circuits involved in complex bacterial behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.