ArticleAngewandte Chemie (International ed. in English)2014
Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- A trackable trinuclear platinum complex for breast cancer treatment.Nucleic acids research · 2025Article
- Fine-tuning the cytotoxicity of ruthenium(II) arene compounds to enhance selectivity against breast cancers.Dalton transactions (Cambridge, England : 2003) · 2023Article
- C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug.Molecules (Basel, Switzerland) · 2023Review
- Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents.Nucleic acids research · 2021Article
- On the Biology of Werner's Complex.Angewandte Chemie (International ed. in English) · 2021Article
- Molecular dynamics simulation of non-covalent interactions between polynuclear platinum(II) complexes and DNA.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Substitution-Inert Polynuclear Platinum Complexes That Inhibit the Activity of DNA Polymerase in Triplex-Forming Templates.Angewandte Chemie (International ed. in English) · 2018Article
- C 3-symmetric opioid scaffolds are pH-responsive DNA condensation agents.Nucleic acids research · 2017Article
- Antiangiogenic platinum through glycan targeting.Chemical science · 2017Article
- The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.Chemical reviews · 2016Review
- Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association.Dalton transactions (Cambridge, England : 2003) · 2015Article
- Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp.Dalton transactions (Cambridge, England : 2003) · 2015Article
- Nucleolar targeting by platinum: p53-independent apoptosis follows rRNA inhibition, cell-cycle arrest, and DNA compaction.Molecular pharmaceutics · 2015Article
- The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes.Nucleic acids research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The trinuclear platinum complexes (TriplatinNC-A [{Pt(NH3 )3 }2 -μ-{trans-Pt(NH3 )2 (NH2 (CH2 )6 NH2 )2 }](6+) , and TriplatinNC [{trans-Pt(NH3 )2 (NH2 (CH2 )6 NH3 (+) )}2 -μ-{trans-Pt(NH3 )2 (NH2 (CH2 )6 NH2 )2 }](8+) ) are biologically active agents that bind to DNA through noncovalent (hydrogen bonding, electrostatic) interactions. Herein, we show that TriplatinNC condenses DNA with a much higher potency than conventional DNA condensing agents. Both complexes induce aggregation of small transfer RNA molecules, and TriplatinNC in particular completely inhibits DNA transcription at lower concentrations than naturally occurring spermine. Topoisomerase I-mediated relaxation of supercoiled DNA was inhibited by TriplatinNC-A and TriplatinNC at concentrations which were 60 times and 250 times lower than that of spermine. The mechanisms for the biological activity of TriplatinNC-A and TriplatinNC may be associated with their ability to condense/aggregate nucleic acids with consequent inhibitory effects on crucial enzymatic activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.