ArticleHuman brain mapping2015
Interhemispheric somatosensory differences in chronic pain reflect abnormality of the healthy side.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of body perception disturbances in complex regional pain syndrome: A systematic review using the COSMIN guideline.European journal of pain (London, England) · 2022Pooled it
- Induced sensorimotor brain plasticity controls pain in phantom limb patients.Nature communications · 2016Trial
- Tactile acuity improves during acute experimental pain of the limb.Pain reports · 2023Article
- Body image and perception among adults with and without phantom limb pain.PM & R : the journal of injury, function, and rehabilitation · 2023Article
- Virtual reality in managing Complex Regional Pain Syndrome (CRPS): a scoping review.Frontiers in neurology · 2023Article
- Different Types of Pain in Complex Regional Pain Syndrome Require a Personalized Treatment Strategy.Journal of pain research · 2023Review
- VR for Pain Relief.Current topics in behavioral neurosciences · 2023Article
- Is there hemispheric specialization in the chronic pain brain?Experimental neurology · 2022Review
- From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome.Drugs · 2022Review
- Altered bodily perceptions in chronic neuropathic pain conditions and implications for treatment using immersive virtual reality.Frontiers in human neuroscience · 2022Review
- Article
- Graded motor imagery modifies movement pain, cortical excitability and sensorimotor function in complex regional pain syndrome.Brain communications · 2021Article
- Neuropsychological Changes in Complex Regional Pain Syndrome (CRPS).Behavioural neurology · 2020Review
- Fine-Grained Mapping of Cortical Somatotopies in Chronic Complex Regional Pain Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Topographic Somatosensory Imagery for Real-Time fMRI Brain-Computer Interfacing.Frontiers in human neuroscience · 2019Article
- Disrupted interhemispheric functional coordination in patients with chronic low back-related leg pain: a multiscale frequency-related homotopic connectivity study.Journal of pain research · 2019Article
- Complex regional pain syndrome - phenotypic characteristics and potential biomarkers.Nature reviews. Neurology · 2018Review
- Sensory gating in the ipsilateral somatosensory cortex during voluntary activity: what might this mean for chronic limb pain?The Journal of physiology · 2018Article
- A critical evaluation of validity and utility of translational imaging in pain and analgesia: Utilizing functional imaging to enhance the process.Neuroscience and biobehavioral reviews · 2018Review
- Evidence of motor system reorganization in complex regional pain syndrome type 1: A case report.Canadian journal of pain = Revue canadienne de la douleur · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
It is widely accepted that complex regional pain syndrome (CRPS) is associated with shrinkage of the primary somatosensory cortex (S1) representation of the affected limb. However, supporting evidence is surprisingly limited and may be compromised by high risk of bias. This study compared the S1 spatial representation of the hand in 17 patients with upper-limb CRPS to 16 healthy controls, using functional MRI. Innocuous vibration was delivered to digits one (D1) and five (D5) in a block-design. Resultant activation maxima were located within a bilateral S1 mask, determined a priori. Distance between D1 and D5 activation maxima, calculated for both hands, was used as a measure of S1 representation. Analyses were blinded to group and hand. In patients, S1 representation was smaller for the affected hand than it was for the healthy hand (t(11) = 2.02, P = 0.03), as predicted. However, S1 representation of the affected hand was no different to that of either hand in controls. Critically, S1 representation of the healthy hand of patients was larger than that of controls' hands. CRPS seems to be associated with an enlarged representation of the healthy hand, not a smaller representation of the affected hand. These findings raise important questions about neuroplasticity in CRPS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.