ArticleJournal of cellular and molecular medicine2014
Cell membrane damage is involved in the impaired survival of bone marrow stem cells by oxidized low-density lipoprotein.
Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
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- Oxidative Stress, Endothelial Dysfunction, andAntioxidants & redox signaling · 2024Review
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- Effect of HO-1-modified BMMSCs on immune function in liver transplantation.Scientific reports · 2022Article
- Ultrarapid lytic granule release from CTLs activates CaScience advances · 2022Article
- Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration.Current opinion in pharmacology · 2021Review
- A surfactant polymer wound dressing protects human keratinocytes from inducible necroptosis.Scientific reports · 2021Article
- Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death.Journal of cell science · 2021Article
- Periosteum progenitors could stimulate bone regeneration in aged murine bone defect model.Journal of cellular and molecular medicine · 2020Article
- Orally administered gadolinium orthovanadate GdVOWiener medizinische Wochenschrift (1946) · 2020Article
- N-acetylcysteine prevents oxidized low-density lipoprotein-induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells.Journal of cellular and molecular medicine · 2020Article
- The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury.Stem cell research & therapy · 2019Article
- Mesenchymal Stem Cells Alleviate Acute Lung Injury and Inflammatory Responses Induced by Paraquat Poisoning.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling.Journal of the American Heart Association · 2019Article
- Article
- Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds.Biophysical journal · 2017Article
- Effects of heme oxygenase-1-modified bone marrow mesenchymal stem cells on microcirculation and energy metabolism following liver transplantation.World journal of gastroenterology · 2017Article
- Heme oxygenase-1-transduced bone marrow mesenchymal stem cells in reducing acute rejection and improving small bowel transplantation outcomes in rats.Stem cell research & therapy · 2016Article
- Hyperlipidemia induced by high-fat diet enhances dentin formation and delays dentin mineralization in mouse incisor.Journal of molecular histology · 2016Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Cell therapy with bone marrow stem cells (BMSCs) remains a viable option for tissue repair and regeneration. A major challenge for cell therapy is the limited cell survival after implantation. This study was to investigate the effect of oxidized low-density lipoprotein (ox-LDL, naturally present in human blood) on BMSC injury and the effect of MG53, a tissue repair protein, for the improvement of stem cell survival. Rat bone marrow multipotent adult progenitor cells (MAPCs) were treated with ox-LDL, which caused significant cell death as reflected by the increased LDH release to the media. Exposure of MAPCs to ox-LDL led to entry of fluorescent dye FM1-43 measured under confocal microscope, suggesting damage to the plasma membrane. Ox-LDL also generated reactive oxygen species (ROS) as measured with electron paramagnetic resonance spectroscopy. While antioxidant N-acetylcysteine completely blocked ROS production from ox-LDL, it failed to prevent ox-LDL-induced cell death. When MAPCs were treated with the recombinant human MG53 protein (rhMG53) ox-LDL induced LDH release and FM1-43 dye entry were significantly reduced. In the presence of rhMG53, the MAPCs showed enhanced cell survival and proliferation. Our data suggest that membrane damage induced by ox-LDL contributed to the impaired survival of MAPCs. rhMG53 treatment protected MAPCs against membrane damage and enhanced their survival which might represent a novel means for improving efficacy for stem cell-based therapy for treatment of diseases, especially in setting of hyperlipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.