ArticleArchives of physical medicine and rehabilitation2015
Focal hand dystonia: individualized intervention with repeated application of repetitive transcranial magnetic stimulation.
Article in Archives of physical medicine and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- "Tapping" into neural inhibition in focal hand dystonia: an evaluation of a finger-tapping task using TMS and fMRI.Journal of neurology · 2026Article
- Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene.Dystonia (Lausanne, Switzerland) · 2025Article
- Applications of Transcranial Magnetic Stimulation for Understanding and Treating Dystonia.Advances in neurobiology · 2023Review
- Suitability of Automated Writing Measures for Clinical Trial Outcome in Writer's Cramp.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Effects of non-invasive brain stimulation in dystonia: a systematic review and meta-analysis.Therapeutic advances in neurological disorders · 2022Article
- Transcranial Magnetic Stimulation in Tremor Syndromes: Pathophysiologic Insights and Therapeutic Role.Frontiers in neurology · 2021Review
- Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations.Journal of neurologic physical therapy : JNPT · 2017Article
- Stepping Up to Rethink the Future of Rehabilitation: IV STEP Considerations and Inspirations.Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association · 2017Article
- Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Therapeutic Use of Non-invasive Brain Stimulation in Dystonia.Frontiers in neuroscience · 2017Review
- Corticospinal excitability measurements using transcranial magnetic stimulation are valid with intramuscular electromyography.PloS one · 2017Article
- Research Priorities in Limb and Task-Specific Dystonias.Frontiers in neurology · 2017Review
- Non-Invasive Brain Stimulation for Treatment of Focal Hand Dystonia: Update and Future Direction.Journal of movement disorders · 2016Review
- Contribution of TMS and rTMS in the Understanding of the Pathophysiology and in the Treatment of Dystonia.Frontiers in neural circuits · 2016Review
- It takes two: noninvasive brain stimulation combined with neurorehabilitation.Archives of physical medicine and rehabilitation · 2015Article
- Translating novel findings of perceptual-motor codes into the neuro-rehabilitation of movement disorders.Frontiers in behavioral neuroscience · 2015Article
- Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia.Frontiers in human neuroscience · 2015Article
- Transcranial magnetic stimulation and functional magnet resonance imaging evaluation of adductor spasmodic dysphonia during phonation.Brain stimulationArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo examine for individual factors that may predict response to inhibitory repetitive transcranial magnetic stimulation (rTMS) in focal hand dystonia (FHD); to present the method for determining optimal stimulation to increase inhibition in a given patient; and to examine individual responses to prolonged intervention.
designSingle-subject design to determine optimal parameters to increase inhibition for a given subject and to use the selected parameters once per week for 6 weeks, with 1-week follow-up, to determine response.
settingClinical research laboratory.
participantsA volunteer sample of subjects with FHD (N = 2). One participant had transcranial magnetic stimulation responses indicating impaired inhibition, and the other had responses within normative limits.
interventionsThere were 1200 pulses of 1-Hz rTMS delivered using 4 different stimulation sites/intensity combinations: primary motor cortex at 90% or 110% of resting motor threshold (RMT) and dorsal premotor cortex (PMd) at 90% or 110% of RMT. The parameters producing the greatest within-session increase in cortical silent period (CSP) duration were then used as the intervention.
main outcome measuresResponse variables included handwriting pressure and velocity, subjective symptom rating, CSP, and short latency intracortical inhibition and facilitation.
resultsThe individual with baseline transcranial magnetic stimulation responses indicating impaired inhibition responded favorably to the repeated intervention, with reduced handwriting force, an increase in the CSP, and subjective report of moderate symptom improvement at 1-week follow-up. The individual with normative baseline responses failed to respond to the intervention. In both subjects, 90% of RMT to the PMd produced the greatest lengthening of the CSP and was used as the intervention.
conclusionsAn individualized understanding of neurophysiological measures can be an indicator of responsiveness to inhibitory rTMS in focal dystonia, with further work needed to determine likely responders versus nonresponders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.