ArticleThorax2015
Children and young adults with CF in the USA have better lung function compared with the UK.
Article in Thorax, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association).Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023Guideline
- Perspective of the European Cystic Fibrosis Society on Improving Global Cystic Fibrosis Care.Pediatric pulmonology · 2026Article
- Unmasking the true value of cystic fibrosis transmembrane conductance regulator modulators.ERJ open research · 2025Article
- Quality of anthropometric data measured in children and adolescents with cystic fibrosis: a scoping review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- Article
- The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Seasonal variation of lung function in cystic fibrosis: longitudinal modeling to compare a Midwest US cohort to international populations.The Science of the total environment · 2021Article
- Factors associated with severe lung disease in an adult population with cystic fibrosis: a single-center experienceTurkish journal of medical sciences · 2020Article
- Healthcare expenditures for privately insured US patients with cystic fibrosis, 2010-2016.Pediatric pulmonology · 2018Article
- Pragmatic criteria to define chronic pseudomonas aeruginosa infection among adults with cystic fibrosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- The importance of data issues when comparing cystic fibrosis registry outcomes between countries: Are annual review FEVJournal of evaluation in clinical practice · 2018Article
- Comparison of Nutrition and Lung Function Outcomes in Patients with Cystic Fibrosis Living in Canada and the United States.American journal of respiratory and critical care medicine · 2018Article
- Data Resource Profile: The UK Cystic Fibrosis Registry.International journal of epidemiology · 2018Article
- Rescue therapy within the UK Cystic Fibrosis Registry: An exploration of predictors of intravenous antibiotic use amongst adults with CF.Respirology (Carlton, Vic.) · 2018Article
- Comparative Effectiveness Research in Pediatric Respiratory Disease: Promise and Pitfalls.Paediatric drugs · 2018Review
- Does current reporting of lung function by the UK cystic fibrosis registry allow a fair comparison of adult centres?Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2017Article
- Survival Comparison of Patients With Cystic Fibrosis in Canada and the United States: A Population-Based Cohort Study.Annals of internal medicine · 2017Article
- Key paediatric messages from Amsterdam.ERJ open research · 2016Article
- Cystic fibrosis.Nature reviews. Disease primers · 2015Review
- Comparing cystic fibrosis outcomes across the pond.Thorax · 2015Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundPeople with cystic fibrosis (CF) are managed differently in the USA and UK providing an opportunity to learn from differences in practice patterns.
objectivesTo compare cross-sectional demographics, practice patterns and clinical outcomes between US and UK CF patients.
methodsThis was a cross-sectional study using 2010 data from patients in the US Cystic Fibrosis Foundation and the UK Cystic Fibrosis patient registries. The a priori outcome measures of interest were lung function and nutritional status. Descriptive statistics and two sample comparisons were performed. Stratification and multivariable linear regression were used to adjust for confounding.
resultsThe study cohort included 13 777 children and 11 058 adults from the USA and 3968 children and 3965 adults from the UK. In children, mean body mass index centiles were similar. Lung function (FEV1 and FVC% predicted) was significantly higher in US patients ages 6-25 years of age. In a regression model adjusted for only age, FEV1% predicted was on average 3.31% of predicted (95% CI 2.65 to 3.96) higher in the USA compared with the UK. When adjusted for age, age at diagnosis, gender, pancreatic insufficiency and genotype, FEV1% predicted was on average 3.03% of predicted (95% CI 2.37 to 3.69) higher in the USA compared with the UK These differences persisted despite adjustment for possible confounders. Hypertonic saline and dornase alfa were much more commonly prescribed in US children.
conclusionsChildren and young adults with CF have better lung function in the USA compared with the UK despite similar nutritional status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.