Trial reportStroke2014
Complication rates and center enrollment volume in the carotid revascularization endarterectomy versus stenting trial.
2 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)
Perioperative Risk and Clinical Efficacy Study of Cervical Artery Stenosis Patients Through the Integration of Multimodal Imaging and Computational Fluid Dynamics
Who cites it
7 citing papers in PubMed.
- To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux.Frontiers in medicine · 2025Article
- Usefulness of CHAThe international journal of cardiovascular imaging · 2021Article
- The Potential Impact of "Take the Volume Pledge" on Outcomes After Carotid Artery Stenting.Neurosurgery · 2020Article
- Perioperative Blood Pressure Control in Carotid Artery Stenosis Patients With Carotid Angioplasty Stenting: A Retrospective Analysis of 173 Cases.Frontiers in neurology · 2020Article
- In-stent restenosis associated with dual-layer Roadsaver carotid artery stent: a retrospective single-center study.La Radiologia medica · 2019Article
- Trends in Hospital Volume and Failure to Rescue for Pancreatic Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- Cerebral Air Embolism and Vasospasm after Carotid Revascularization: A Case Report.Case reports in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Nicole R GonzalesFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Bart M DemaerschalkFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Jenifer H VoeksFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
MeeLee TomFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
George HowardFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Alice J SheffetFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Lawrence GarciaFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Daniel G ClairFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
John BarrFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Steven OrlowFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Thomas G BrottFrom the Department of Neurology, University of Texas Science Health Center, Houston (N.R.G.); Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.M.D.); Department of Neurosciences, Medical University of South Carolina, Medical University of South Carolina Stroke Center, Charleston (J.H.V.); Department of Surgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark (M.T., A.J.S., T.G.B.); Department of Epidemiology, University of Alabama at Birmingham (G.H.); Division of Cardiology and Vascular Medicine, Interventional Cardiology, Steward St. Elizabeth's Medical Center, Boston, MA (L.G.); Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH (D.G.C.); Departments of Radiology and Neurological Surgery, University of Texas Southwestern Medical Center, Dallas (J.B.); Department of Cardiology, Northern Indiana Research Alliance, Lutheran Hospital of Indiana, Ft. Wayne (S.O.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
CREST Investigators
Funding
Carotid Revascularization Endarterectomy vs. Stenting Trial: Long Term Follow-upU01NS038384 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BROTT, THOMAS G, SHEFFET, ALICE J · 2011 to 2016
$15.4MCenter for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4MNCATS NIH HHS UL1 TR000371NINDS NIH HHS U01 NS038384
Abstract
background and purposeEvidence indicates that center volume of cases affects outcomes for both carotid endarterectomy and stenting. We evaluated the effect of enrollment volume by site on complication rates in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST).
methodsThe primary composite end point was any stroke, myocardial infarction, or death within 30 days or ipsilateral stroke in follow-up. The 477 approved surgeons performed >12 procedures per year with complication rates <3% for asymptomatic patients and <5% for symptomatic patients; 224 interventionists were certified after a rigorous 2 step credentialing process. CREST centers were divided into tertiles based on the number of patients enrolled into the study, with Group 1 sites enrolling <25 patients, Group 2 sites enrolling 25 to 51 patients, and Group 3 sites enrolling >51 patients. Differences in periprocedural event rates for the primary composite end point and its components were compared using logistic regression adjusting for age, sex, and symptomatic status within site-volume level.
resultsThe safety of carotid angioplasty and stenting and carotid endarterectomy did not vary by site-volume during the periprocedural period as indicated by occurrence of the primary end point (P=0.54) or by stroke and death (P=0.87). A trend toward an inverse relationship between center enrollment volume and complications was mitigated by adjustment for known risk factors.
conclusionsComplication rates were low in CREST and were not associated with center enrollment volume. The data are consistent with the value of rigorous training and credentialing in trials evaluating endovascular devices and surgical procedures. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00004732.
Indexed as
AgedAngioplastyCarotid StenosisCerebral RevascularizationEndarterectomy, CarotidFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesRisk FactorsSingle-Blind MethodStentsTreatment Outcomecarotid endarterectomycarotid stenosisrandomized controlled trialstentingstroketraining
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT00004732ClinicalTrials.gov
NCT06294496ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.