ArticleAutism research : official journal of the International Society for Autism Research2015
Left-hemispheric microstructural abnormalities in children with high-functioning autism spectrum disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies.Molecular autism · 2020Pooled it
- Asymmetric neural dynamics of visuospatial attention in autism spectrum disorder.bioRxiv : the preprint server for biology · 2026Article
- Air Pollution Exposure, Prefrontal Connectivity, and Emotional Behavior in Early Adolescence.Research report (Health Effects Institute) · 2025Article
- Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder.BMC sports science, medicine & rehabilitation · 2024Article
- Application of Multimodal MRI in the Early Diagnosis of Autism Spectrum Disorders: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex.Human genomics · 2023Article
- Lateralized Decrease of Parvalbumin+ Cells in the Somatosensory Cortex of ASD Models Is Correlated with Unilateral Tactile Hypersensitivity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children.JAMA network open · 2021Article
- Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults.Journal of autism and developmental disorders · 2021Article
- The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Network curvature as a hallmark of brain structural connectivity.Nature communications · 2019Article
- Cognitive Effects of Air Pollution Exposures and Potential Mechanistic Underpinnings.Current environmental health reports · 2017Review
- Candidate Biomarkers in Children with Autism Spectrum Disorder: A Review of MRI Studies.Neuroscience bulletin · 2017Review
- Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Prolonged auditory brainstem responses in infants with autism.Autism research : official journal of the International Society for Autism Research · 2016Article
- Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey.Frontiers in human neuroscience · 2016Review
- Neuroimaging endophenotypes in autism spectrum disorder.CNS spectrums · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Current theories of the neurobiological basis of autism spectrum disorder (ASD) posit an altered pattern of connectivity in large-scale brain networks. Here we used diffusion tensor imaging to investigate the microstructural properties of the white matter (WM) that mediates interregional connectivity in 36 high-functioning children with ASD (HF-ASD) as compared with 37 controls. By employing an atlas-based analysis using large deformation diffeometric morphic mapping registration, a widespread but left-lateralized pattern of abnormalities was revealed. The mean diffusivity (MD) of water in the WM of HF-ASD children was significantly elevated throughout the left hemisphere, particularly in the outer-zone cortical WM. Across diagnostic groups, there was a significant effect of age on left-hemisphere MD, with a similar reduction in MD during childhood in both typically developing and HF-ASD children. The increased MD in children with HF-ASD suggests hypomyelination and may reflect increased short-range cortico-cortical connections subsequent to early WM overgrowth. These findings also highlight left-hemispheric connectivity as relevant to the pathophysiology of ASD and indicate that the spatial distribution of microstructural abnormalities in HF-ASD is widespread and left-lateralized. This altered left-hemispheric connectivity may contribute to deficits in communication and praxis observed in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.