Evidence map›Paper›PMID 25256068›Full record

ArticleAmerican journal of ophthalmology2015

Reproducibility of retinal nerve fiber layer thickness measures using eye tracking in children with nonglaucomatous optic neuropathy.

Raneem D Rajjoub, Carmelina Trimboli-Heidler, Roger J Packer, Robert A Avery

Abstract read
In one paragraph

Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Longitudinal changes in the position and thickness of the peak peripapillary retinal nerve fiber layer in school children.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Article
  2. Article
  3. Article
  4. Optical coherence tomography as a marker of vision in children with optic pathway gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Review
  5. Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Raneem D RajjoubGeorge Washington University School of Medicine, Children's National Health System, Washington, DC.
Carmelina Trimboli-HeidlerThe Gilbert Family Neurofibromatosis Institute, Children's National Health System, Washington, DC.
Roger J PackerThe Gilbert Family Neurofibromatosis Institute, Children's National Health System, Washington, DC; Department of Pediatrics, Children's National Health System, Washington, DC; Center for Neuroscience and Behavior, Children's National Health System, Washington, DC; The Brain Tumor Institute, Children's National Health System, Washington, DC.
Robert A AveryThe Gilbert Family Neurofibromatosis Institute, Children's National Health System, Washington, DC; Department of Ophthalmology, Children's National Health System, Washington, DC; Department of Pediatrics, Children's National Health System, Washington, DC; Center for Neuroscience and Behavior, Children's National Health System, Washington, DC. Electronic address: ravery@childrensnational.org.
Children's National · USGeorge Washington University · US

Funding

Visual outcome measures in children with optic Pathway gliomasK23EY022673 · NEI · CHILDREN'S RESEARCH INSTITUTE · PI AVERY, ROBERT ANDREW · 2012 to 2016
$1.1M
NEI NIH HHS K23 EY022673NEI NIH HHS K23-EY022673
6 · The paper itself

Abstract

purposeTo determine the intra- and intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) thickness measures using eye tracking-assisted spectral-domain optical coherence tomography (SD OCT) in children with nonglaucomatous optic neuropathy.

designProspective longitudinal study.

methodsCircumpapillary RNFL thickness measures were acquired with SD OCT using the eye-tracking feature at 2 separate study visits. Children with normal and abnormal vision (visual acuity ≥ 0.2 logMAR above normal and/or visual field loss) who demonstrated clinical and radiographic stability were enrolled. Intra- and intervisit reproducibility was calculated for the global average and 9 anatomic sectors by calculating the coefficient of variation and intraclass correlation coefficient.

resultsForty-two subjects (median age 8.6 years, range 3.9-18.2 years) met inclusion criteria and contributed 62 study eyes. Both the abnormal and normal vision cohort demonstrated the lowest intravisit coefficient of variation for the global RNFL thickness. Intervisit reproducibility remained good for those with normal and abnormal vision, although small but statistically significant increases in the coefficient of variation were observed for multiple anatomic sectors in both cohorts. The magnitude of visual acuity loss was significantly associated with the global (ß = 0.026, P < .01) and temporal sector coefficient of variation (ß = 0.099, P < .01).

conclusionSD OCT with eye tracking demonstrates highly reproducible RNFL thickness measures. Subjects with vision loss demonstrate greater intra- and intervisit variability than those with normal vision.

Indexed as

AdolescentChildChild, PreschoolFemaleHumansLongitudinal StudiesMaleNerve FibersOptic Nerve DiseasesProspective StudiesRegression AnalysisReproducibility of ResultsRetinal Ganglion CellsTomography, Optical CoherenceVisual Acuity

Identifiers

PMID25256068
PMCPMC4455020
OpenAlexW2169434906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.