Evidence map›Paper›PMID 25255989›Full record

ReviewThe Journal of pathology2015

Pathogenesis of varicelloviruses in primates.

Werner J D Ouwendijk, Georges M G M Verjans

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026
    Review
  2. Review
  3. Animal models of human herpesvirus infection.Animal models and experimental medicine · 2025
    Review
  4. Article
  5. Article
  6. Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis.Current topics in microbiology and immunology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Insights into the pathogenesis of varicella viruses.Current clinical microbiology reports · 2019
    Article
  11. Article
  12. Review
  13. Nonhuman primate models of human viral infections.Nature reviews. Immunology · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Werner J D OuwendijkDepartment of Viroscience, Erasmus Medical Centre, Rotterdam, The Netherlands.
Georges M G M Verjans
Erasmus University Rotterdam · NL

Funding

VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2009 to 2023
$30.3M
NIA NIH HHS AG032958NIA NIH HHS P01 AG032958
6 · The paper itself

Abstract

Varicelloviruses in primates comprise the prototypic human varicella-zoster virus (VZV) and its non-human primate homologue, simian varicella virus (SVV). Both viruses cause varicella as a primary infection, establish latency in ganglionic neurons and reactivate later in life to cause herpes zoster in their respective hosts. VZV is endemic worldwide and, although varicella is usually a benign disease in childhood, VZV reactivation is a significant cause of neurological disease in the elderly and in immunocompromised individuals. The pathogenesis of VZV infection remains ill-defined, mostly due to the species restriction of VZV that impedes studies in experimental animal models. SVV infection of non-human primates parallels virological, clinical, pathological and immunological features of human VZV infection, thereby providing an excellent model to study the pathogenesis of varicella and herpes zoster in its natural host. In this review, we discuss recent studies that provided novel insight in both the virus and host factors involved in the three elementary stages of Varicellovirus infection in primates: primary infection, latency and reactivation.

Indexed as

PrimatesAnimalsBiopsyDisease Models, AnimalGenotypeHerpesviridae InfectionsHost-Pathogen InteractionsHumansPathology, MolecularPredictive Value of TestsVaricellovirusVirologyVirulenceVirus ActivationVirus Latencydisseminationhumansimmunitylatencynon-human primatesprimary infectionreactivationsimian varicella virusvaricella-zoster virus

Identifiers

PMID25255989
PMCPMC4268028
OpenAlexW1479829579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.