Evidence map›Paper›PMID 25255882›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Stable small quantum dots for synaptic receptor tracking on live neurons.

En Cai, Pinghua Ge, Sang Hak Lee, Okunola Jeyifous, Yong Wang, Yanxin Liu, Katie M Wilson, Sung Jun Lim, Michelle A Baird, John E Stone and 7 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Recent Advances in Single-Molecule Tracking and Imaging Techniques.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023
    Review
  6. Review
  7. Structural Design of Multidentate Copolymers as Compact Quantum Dot Coatings for Live-Cell Single-Particle Imaging.Chemistry of materials : a publication of the American Chemical Society · 2022
    Article
  8. Antibody Self-Assembly Maximizes Cytoplasmic Immunostaining Accuracy of Compact Quantum Dots.Chemistry of materials : a publication of the American Chemical Society · 2021
    Article
  9. Quantum Dots for Improved Single-Molecule Localization Microscopy.The journal of physical chemistry. B · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Minimizing ATP depletion by oxygen scavengers for single-molecule fluorescence imaging in live cells.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

En CaiDepartment of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, 1110 W Green St., Urbana, IL 61801 (USA).
Pinghua Ge
Sang Hak Lee
Okunola Jeyifous
Yong Wang
Yanxin Liu
Katie M Wilson
Sung Jun Lim
Michelle A Baird
John E Stone
Kwan Young Lee
Michael W Davidson
Hee Jung Chung
Klaus Schulten
Andrew M Smith
William N Green
Paul R Selvin

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
The Neuronal alpha-bungarotoxin Binding SiteR01NS043782 · NINDS · UNIVERSITY OF CHICAGO · PI GREEN, WILLIAM · 2003 to 2012
$3.0M
Single-molecule imaging with super-resolutionR01GM086214 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TING, ALICE Y · 2009 to 2012
$2.4M
Different components of nicotine-induced upregulation of nicotinic receptors - E. Hunpatin SupplementR01DA035430 · NIDA · UNIVERSITY OF CHICAGO · PI GREEN, WILLIAM · 2013 to 2017
$2.3M
Next-Generation Quantum Dots for Molecular and Cellular Imaging of CancerR00CA153914 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SMITH, ANDREW MICHAEL · 2012 to 2014
$709k
Small Quantum Dots for Super-Resolution of Neuronal Sub-Synaptic StructuresR21NS087413 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SELVIN, PAUL R · 2014 to 2015
$402k
The Neuronal alpha-bungarotoxin Binding SiteR56NS043782 · NINDS · UNIVERSITY OF CHICAGO · PI GREEN, WILLIAM · 2008 to 2008
$308k
NCI NIH HHS R00 CA153914NIDA NIH HHS R01 DA035430NIGMS NIH HHS 5P41GM104601NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM086214NINDS NIH HHS R01 NS043782NINDS NIH HHS R21 NS087413NINDS NIH HHS R56 NS043782
6 · The paper itself

Abstract

We developed a coating method to produce functionalized small quantum dots (sQDs), about 9 nm in diameter, that were stable for over a month. We made sQDs in four emission wavelengths, from 527 to 655 nm and with different functional groups. AMPA receptors on live neurons were labeled with sQDs and postsynaptic density proteins were visualized with super-resolution microscopy. Their diffusion behavior indicates that sQDs access the synaptic clefts significantly more often than commercial QDs.

Indexed as

AnimalsCells, CulturedFluorescent DyesMicroscopy, FluorescenceNeuronsOptical ImagingQuantum DotsRatsReceptors, AMPAFluorescent DyesReceptors, AMPAAMPA receptorsfluorescent probesquantum dotssingle-molecule studies

Identifiers

PMID25255882
PMCPMC4240739

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.