ArticleJournal of the Association for Research in Otolaryngology : JARO2014
Effects of unilateral acoustic trauma on tinnitus-related spontaneous activity in the inferior colliculus.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 60 citations in OpenAlex.
- Sound-evoked plasticity differentiates tinnitus from non-tinnitus mice.Frontiers in neuroscience · 2025Article
- Transcriptional profile changes caused by noise-induced tinnitus in the cochlear nucleus and inferior colliculus of the rat.Annals of medicine · 2024Article
- Eric Daniel Young.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Subcortical auditory system in tinnitus with normal hearing: insights from electrophysiological perspective.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.The Journal of physiology · 2023Article
- Depolarization shift in the resting membrane potential of inferior colliculus neurons explains their hyperactivity induced by an acoustic trauma.Frontiers in neuroscience · 2023Article
- Comparison of two behavioral tests for tinnitus assessment in mice.Frontiers in behavioral neuroscience · 2022Article
- What's the buzz? The neuroscience and the treatment of tinnitus.Physiological reviews · 2021Review
- Effect of Unilateral Acoustic Trauma on Neuronal Firing Activity in the Inferior Colliculus of Mice.Frontiers in synaptic neuroscience · 2021Article
- Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review.Brain sciences · 2020Review
- Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure.International journal of molecular medicine · 2019Article
- Review
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.Brain structure & function · 2018Article
- Addressing variability in the acoustic startle reflex for accurate gap detection assessment.Hearing research · 2018Article
- Effects of Acoustic Environment on Tinnitus Behavior in Sound-Exposed Rats.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Behavioral Animal Model of the Emotional Response to Tinnitus and Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus.Frontiers in systems neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This study describes the long-term effects of sound-induced cochlear trauma on spontaneous discharge rates in the central nucleus of the inferior colliculus (ICC). As in previous studies, single-unit recordings in Sprague-Dawley rats revealed pervasive increases in spontaneous discharge rates. Based on differences in their sources of input, it was hypothesized that physiologically defined neural populations of the auditory midbrain would reveal the brainstem sources that dictate ICC hyperactivity. Abnormal spontaneous activity was restricted to target neurons of the ventral cochlear nucleus. Nearly identical patterns of hyperactivity were observed in the contralateral and ipsilateral ICC. The elevation in spontaneous activity extended to frequencies well below and above the region of maximum threshold shift. This lack of frequency organization suggests that ICC hyperactivity may be influenced by regions of the brainstem that are not tonotopically organized. Sound-induced hyperactivity is often observed in animals with behavioral signs of tinnitus. Prior to electrophysiological recording, rats were screened for tinnitus by measuring gap pre-pulse inhibition of the acoustic startle reflex (GPIASR). Rats with positive phenotypes did not exhibit unique patterns of ICC hyperactivity. This ambiguity raises concerns regarding animal behavioral models of tinnitus. If our screening procedures were valid, ICC hyperactivity is observed in animals without behavioral indications of the disorder. Alternatively, if the perception of tinnitus is strictly linked to ongoing ICC hyperactivity, our current behavioral approach failed to provide a reliable assessment of tinnitus state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.