ArticleAutism research : official journal of the International Society for Autism Research2014
Predicting health utilities for children with autism spectrum disorders.
Article in Autism research : official journal of the International Society for Autism Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A systematic review of condition-specific preference-based measures used in young people and their valuation methods.Journal of patient-reported outcomes · 2024Pooled it
- Predictors of Health-Related Quality of Life in Neurodivergent Children: A Systematic Review.Clinical child and family psychology review · 2024Pooled it
- Outcome measures for economic evaluations and cost-effectiveness analyses of interventions for people with intellectual disabilities: A methodological systematic review.Journal of applied research in intellectual disabilities : JARID · 2023Pooled it
- Pooled it
- Interventions based on early intensive applied behaviour analysis for autistic children: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- The potential cost-effectiveness of novel cord blood therapies in children with autism spectrum disorder.PloS one · 2023Trial
- Economic Evaluation of Interventions for Children with Neurodevelopmental Disorders: Practical Guidance.PharmacoEconomics · 2026Review
- Quality of Life and Societal Cost in Autistic Children: An Exploratory Comparative Study Pre- and Post-Diagnosis.Journal of autism and developmental disorders · 2026Article
- Economic Evaluation of Early Interventions for Autistic Children: A Scoping Review.Journal of autism and developmental disorders · 2024Article
- Predictors of health-related quality of life for children with neurodevelopmental conditions.Scientific reports · 2024Article
- Application of validated mapping algorithms between generic PedsQL scores and utility values to individuals with sickle cell disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Mapping PedsQL™ Generic Core Scales to EQ-5D-3L utility scores in transfusion-dependent thalassemia patients.The European journal of health economics : HEPAC : health economics in prevention and care · 2021Article
- Mapping PedsQLQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Generic preference-based health-related quality of life in children with neurodevelopmental disorders: a scoping review.Developmental medicine and child neurology · 2020Article
- Cost-Effectiveness of MRI-Based Identification of Presymptomatic Autism in a High-Risk Population.Frontiers in psychiatry · 2020Article
- Economic Evaluation of Interventions for Children with Neurodevelopmental Disorders: Opportunities and Challenges.Applied health economics and health policy · 2017Article
- Mapping CHU9D Utility Scores from the PedsQLPharmacoEconomics · 2017Article
- National Database for Autism Research (NDAR): Big Data Opportunities for Health Services Research and Health Technology Assessment.PharmacoEconomics · 2016Article
- Preferred reporting items for studies mapping onto preference-based outcome measures: the MAPS statement.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Treatment for Sleep Problems in Children with Autism and Caregiver Spillover Effects.Journal of autism and developmental disorders · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Comparative effectiveness of interventions for children with autism spectrum disorders (ASDs) that incorporates costs is lacking due to the scarcity of information on health utility scores or preference-weighted outcomes typically used for calculating quality-adjusted life years (QALYs). This study created algorithms for mapping clinical and behavioral measures for children with ASDs to health utility scores. The algorithms could be useful for estimating the value of different interventions and treatments used in the care of children with ASDs. Participants were recruited from two Autism Treatment Network sites. Health utility data based on the Health Utilities Index Mark 3 (HUI3) for the child were obtained from the primary caregiver (proxy-reported) through a survey (N = 224). During the initial clinic visit, proxy-reported measures of the Child Behavior Checklist, Vineland II Adaptive Behavior Scales, and the Pediatric Quality of Life Inventory 4.0 (start measures) were obtained and then merged with the survey data. Nine mapping algorithms were developed using the HUI3 scores as dependent variables in ordinary least squares regressions along with the start measures, the Autism Diagnostic Observation Schedule, to measure severity, child age, and cognitive ability as independent predictors. In-sample cross-validation was conducted to evaluate predictive accuracy. Multiple imputation techniques were used for missing data. The average age for children with ASDs in this study was 8.4 (standard deviation = 3.5) years. Almost half of the children (47%) had cognitive impairment (IQ ≤ 70). Total scores for all of the outcome measures were significantly associated with the HUI3 score. The algorithms can be applied to clinical studies containing start measures of children with ASDs to predict QALYs gained from interventions.
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Registered trials
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