ArticleThe Journal of cell biology1989
The 110-kD protein-calmodulin complex of the intestinal microvillus (brush border myosin I) is a mechanoenzyme.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 103 citations in OpenAlex.
- MYO1B in human disease: an actin-based motor linking membrane trafficking to oncogenic signaling, metastasis, and vascular aging.Frontiers in oncology · 2026Review
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.Cytoskeleton (Hoboken, N.J.) · 2014Review
- Regulation and control of myosin-I by the motor and light chain-binding domains.Trends in cell biology · 2013Review
- Calcium regulation of myosin-I tension sensing.Biophysical journal · 2012Article
- Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.Nature reviews. Molecular cell biology · 2010Review
- Control of cell membrane tension by myosin-I.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The enterocyte microvillus is a vesicle-generating organelle.The Journal of cell biology · 2009Article
- Myosin-1a powers the sliding of apical membrane along microvillar actin bundles.The Journal of cell biology · 2007Article
- WASp is required for the correct temporal morphogenesis of rhabdomere microvilli.The Journal of cell biology · 2004Article
- myoA of Aspergillus nidulans encodes an essential myosin I required for secretion and polarized growth.The Journal of cell biology · 1995Article
- Calmodulin in rat enterocyte: an immunogold electron-microscope study.Cell and tissue research · 1994Article
- Actin binding to lipid-inserted alpha-actinin.Biophysical journal · 1993Article
- Calcium-calmodulin and regulation of brush border myosin-I MgATPase and mechanochemistry.The Journal of cell biology · 1993Article
- Measuring orientation of actin filaments within a cell: orientation of actin in intestinal microvilli.Biophysical journal · 1993Article
- Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family.The Journal of cell biology · 1993Article
- Identification, characterization and cloning of myr 1, a mammalian myosin-I.The Journal of cell biology · 1993Article
- The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility.Molecular biology of the cell · 1993Article
- Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells.The Journal of cell biology · 1993Article
- Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein.The Journal of cell biology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The 110-kD protein-calmodulin complex (110K-CM) of the intestinal brush border serves to laterally tether microvillar actin filaments to the plasma membrane. Results from several laboratories have demonstrated that this complex shares many enzymatic and structural properties with myosin. The mechanochemical potential of purified avian 110K-CM was assessed using the Nitella bead motility assay (Sheetz, M. P., and J. A. Spudich. 1983. Nature (Lond.). 303:31-35). Under low Ca2+ conditions, 110K-CM-coated beads bound to actin cables, but no movement was observed. Using EGTA/calcium buffers (approximately 5-10 microM free Ca2+) movement of 110K-CM-coated beads along actin cables (average rate of approximately 8 nm/s) was observed. The movement was in the same direction as that for beads coated with skeletal muscle myosin. The motile preparations of 110K-CM were shown to be free of detectable contamination by conventional brush border myosin. Based on these and other observations demonstrating the myosin-like properties of 110K-CM, we propose that this complex be named "brush border myosin I."
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.