ArticlePLoS computational biology2014
Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.
Article in PLoS computational biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
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- Patient-Specific Network Connectivity Combined With a Next Generation Neural Mass Model to Test Clinical Hypothesis of Seizure Propagation.Frontiers in systems neuroscience · 2021Article
- Exact neural mass model for synaptic-based working memory.PLoS computational biology · 2020Article
- Unstructured network topology begets order-based representation by privileged neurons.Biological cybernetics · 2020Article
- Critical synchronization and 1/f noise in inhibitory/excitatory rich-club neural networks.Scientific reports · 2019Article
- Degree and centrality-based approaches in network-based variable selection: Insights from the Singapore Longitudinal Aging Study.PloS one · 2019Article
- Modeling driver cells in developing neuronal networks.PLoS computational biology · 2018Article
- Developmental Emergence of Sparse Coding: A Dynamic Systems Approach.Scientific reports · 2017Article
- Cancer-Related Triplets of mRNA-lncRNA-miRNA Revealed by Integrative Network in Uterine Corpus Endometrial Carcinoma.BioMed research international · 2017Article
- Cortical Dynamics in Presence of Assemblies of Densely Connected Weight-Hub Neurons.Frontiers in computational neuroscience · 2017Article
- Long-range synchrony and emergence of neural reentry.Scientific reports · 2016Article
- Structure, Function, and Propagation of Information across Living Two, Four, and Eight Node Degree Topologies.Frontiers in bioengineering and biotechnology · 2016Article
- Network Events on Multiple Space and Time Scales in Cultured Neural Networks and in a Stochastic Rate Model.PLoS computational biology · 2015Article
- Efficient transmission of subthreshold signals in complex networks of spiking neurons.PloS one · 2015Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.
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