ArticlePLoS genetics2014
Evidence for widespread positive and negative selection in coding and conserved noncoding regions of Capsella grandiflora.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed, 183 citations in OpenAlex.
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- The Demographic History of Populations and Genomic Imprinting have Shaped the Transposon Patterns in Arabidopsis lyrata.Molecular biology and evolution · 2025Article
- The population genetics of convergent adaptation in maize and teosinte is not locally restricted.eLife · 2025Article
- Fixation of Expression Divergences by Natural Selection inInternational journal of molecular sciences · 2024Article
- Unveiling the Genome-Wide Consequences of Range Expansion and Mating System Transitions in Primula vulgaris.Genome biology and evolution · 2024Article
- Previously unmeasured genetic diversity explains part of Lewontin's paradox in abioRxiv : the preprint server for biology · 2024Article
- The genetic architecture of the load linked to dominant and recessive self-incompatibility alleles ineLife · 2024Article
- Genetic Causes and Genomic Consequences of Breakdown of Distyly in Linum trigynum.Molecular biology and evolution · 2024Article
- The distribution of fitness effects during adaptive walks using a simple genetic network.PLoS genetics · 2024Article
- Shared evolutionary processes shape landscapes of genomic variation in the great apes.Genetics · 2024Article
- Genomic analyses elucidateEcology and evolution · 2024Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent that both positive and negative selection vary across different portions of plant genomes remains poorly understood. Here, we sequence whole genomes of 13 Capsella grandiflora individuals and quantify the amount of selection across the genome. Using an estimate of the distribution of fitness effects, we show that selection is strong in coding regions, but weak in most noncoding regions, with the exception of 5' and 3' untranslated regions (UTRs). However, estimates of selection on noncoding regions conserved across the Brassicaceae family show strong signals of selection. Additionally, we see reductions in neutral diversity around functional substitutions in both coding and conserved noncoding regions, indicating recent selective sweeps at these sites. Finally, using expression data from leaf tissue we show that genes that are more highly expressed experience stronger negative selection but comparable levels of positive selection to lowly expressed genes. Overall, we observe widespread positive and negative selection in coding and regulatory regions, but our results also suggest that both positive and negative selection on plant noncoding sequence are considerably rarer than in animal genomes.
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