ArticlePLoS pathogens2014
Identification and characterisation of a hyper-variable apoplastic effector gene family of the potato cyst nematodes.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Diversity at the HYP1 locus in potato cyst nematodes does not result from developmentally-programmed somatic mutations.PloS one · 2026Article
- Identification through a transcriptomic approach of candidate genes involved in the adaptation of the cyst nematode Globodera pallida to the potato resistance factor GpaVBMC genomics · 2025Article
- A gene with a thousand alleles: The hyper-variable effectors of plant-parasitic nematodes.Cell genomics · 2024Article
- Evolution of parasitism genes in the plant parasitic nematodes.Scientific reports · 2024Article
- Beet cyst nematode HsSNARE1 interacts with both AtSNAP2 and AtPR1 and promotes disease in Arabidopsis.Journal of advanced research · 2023Article
- Comparative genomics among cyst nematodes reveals distinct evolutionary histories among effector families and an irregular distribution of effector-associated promoter motifs.Molecular ecology · 2023Article
- An eggshell-localised annexin plays a key role in the coordination of the life cycle of a plant-parasitic nematode with its host.PLoS pathogens · 2023Article
- The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.Nature communications · 2022Article
- Morphological characterization reveals new insights into giant cell development of Meloidogyne graminicola on rice.Planta · 2022Article
- Profiling the Proteome of Cyst Nematode-Induced Syncytia on Tomato Roots.International journal of molecular sciences · 2021Article
- Comparative genomics of two inbred lines of the potato cyst nematode Globodera rostochiensis reveals disparate effector family-specific diversification patterns.BMC genomics · 2021Article
- A new esophageal gland transcriptome reveals signatures of large scale de novo effector birth in the root lesion nematode Pratylenchus penetrans.BMC genomics · 2020Article
- Article
- Plant Proteins and Processes Targeted by Parasitic Nematode Effectors.Frontiers in plant science · 2019Review
- A Novel G16B09-Like Effector FromFrontiers in plant science · 2019Article
- Effector gene birth in plant parasitic nematodes: Neofunctionalization of a housekeeping glutathione synthetase gene.PLoS genetics · 2018Article
- Novel global effector mining from the transcriptome of early life stages of the soybean cyst nematode Heterodera glycines.Scientific reports · 2018Article
- The Role of Programmed Cell Death RegulatorFrontiers in plant science · 2018Article
- Article
- Aphid Colonization Affects Potato Root Exudate Composition and the Hatching of a Soil Borne Pathogen.Frontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sedentary endoparasitic nematodes are obligate biotrophs that modify host root tissues, using a suite of effector proteins to create and maintain a feeding site that is their sole source of nutrition. Using assumptions about the characteristics of genes involved in plant-nematode biotrophic interactions to inform the identification strategy, we provide a description and characterisation of a novel group of hyper-variable extracellular effectors termed HYP, from the potato cyst nematode Globodera pallida. HYP effectors comprise a large gene family, with a modular structure, and have unparalleled diversity between individuals of the same population: no two nematodes tested had the same genetic complement of HYP effectors. Individuals vary in the number, size, and type of effector subfamilies. HYP effectors are expressed throughout the biotrophic stages in large secretory cells associated with the amphids of parasitic stage nematodes as confirmed by in situ hybridisation. The encoded proteins are secreted into the host roots where they are detectable by immunochemistry in the apoplasm, between the anterior end of the nematode and the feeding site. We have identified HYP effectors in three genera of plant parasitic nematodes capable of infecting a broad range of mono- and dicotyledon crop species. In planta RNAi targeted to all members of the effector family causes a reduction in successful parasitism.
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Registered trials
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