ArticlePloS one2014
Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001349 (Apheresis Procedures to Obtain Plasma or Leukocytes for In Vitro Studies), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Apheresis Procedures to Obtain Plasma or Leukocytes for In Vitro Studies
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.The New England journal of medicine · 2017Trial
- The emerging roles of eosinophils in immune regulation in health and disease.Frontiers in immunology · 2026Review
- Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution.Nature communications · 2025Article
- Unraveling the Dynamics of Human Filarial Infections: Immunological Responses, Host Manifestations, and Pathogen Biology.Pathogens (Basel, Switzerland) · 2025Review
- Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis.Frontiers in immunology · 2024Article
- Reduced Type 2 Innate Lymphocyte Cell Frequencies in PatentPathogens (Basel, Switzerland) · 2023Article
- Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology.Vaccines · 2022Review
- Effects of helminths on the human immune response and the microbiome.Mucosal immunology · 2022Review
- Tissue-Dependent Adaptations and Functions of Innate Lymphoid Cells.Frontiers in immunology · 2022Review
- NKp46Frontiers in immunology · 2022Article
- Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells.Frontiers in immunology · 2021Review
- Age-Related Dynamics of Circulating Innate Lymphoid Cells in an African Population.Frontiers in immunology · 2020Article
- Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.Scientific reports · 2019Article
- Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.Parasites & vectors · 2019Article
- Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity.International journal of molecular sciences · 2019Review
- Innate Lymphoid Cells in Helminth Infections-Obligatory or Accessory?Frontiers in immunology · 2019Review
- ILC2s-Trailblazers in the Host Response Against Intestinal Helminths.Frontiers in immunology · 2019Review
- Characterization, localization and comparison of c-Kit+ lung cells in never smokers and smokers with and without COPD.BMC pulmonary medicine · 2018Observational
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.International immunopharmacology · 2018Review
- Human innate lymphoid cells (ILCs) in filarial infections.Parasite immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Since innate lymphoid cells (ILCs) have been found to play a role in the immune response to helminth parasites in rodents, we sought to determine their role in human helminth infection. By developing multicolor flow cytometry-based methods to identify and enumerate circulating ILCs and their subsets, we were able to identify a subset of cKit+ ILCs defined as Lineage (Lin)-/CD45+/cKit+/CD127+ that were significantly expanded in the filarial-infected individuals (p=0.0473) as were those cKit+ ILCs that produced IL-13. Additionally, the frequency of these cKit+ ILCs correlated with the frequency of IL-17 producing CD4+ T cells (Th17 cells; p=0.025). To investigate the function of cKit+ ILCs, sorted, highly purified human ILCs were subjected to transcriptional profiling by RNAseq and compared to appropriate control cells. These cKit+ ILCs expressed TLRs, a broad range of cytokines/cytokine receptors and MHC Class II molecules suggesting that these ILCs sense pathogens independent of other cell types. Functional analysis revealed expanded cKit+ ILC-specific transcription and ILC-specific microRNA precursors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.