ArticlePloS one2014
Angiopoietin-1, angiopoietin-2 and bicarbonate as diagnostic biomarkers in children with severe sepsis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.BMC pediatrics · 2026Article
- Circulating and Respiratory Biomarkers in Sepsis-Induced ARDS: Diagnostic and Prognostic Insights - A Narrative Review.Journal of inflammation research · 2026Review
- A Correlation between Sequential Organ Failure Assessment Scores and Biomarkers of Inflammation and Infection in Patients with Sepsis.Current medicinal chemistry · 2026Article
- Integration of metabolic parameters with SOFA score for mortality risk assessment in elderly sepsis: a derivation study.BMC infectious diseases · 2025Article
- Review
- Role of artificial intelligence in pediatric intensive care: a survey of healthcare staff perspectives in Saudi Arabia.Frontiers in pediatrics · 2025Article
- Angiopoietin-2 levels correlates with disease activity in children with nonalcoholic fatty liver disease.Pediatric research · 2022Article
- Systemic Endothelial Activation Is Associated With Early Acute Respiratory Distress Syndrome in Children With Extrapulmonary Sepsis.Critical care medicine · 2020Observational
- Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis.The American journal of tropical medicine and hygiene · 2019Article
- Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium.Shock (Augusta, Ga.) · 2019Observational
- Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.Shock (Augusta, Ga.) · 2017Observational
- Review
- Could Biomarkers Direct Therapy for the Septic Patient?The Journal of pharmacology and experimental therapeutics · 2016Review
- Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency department.Critical care (London, England) · 2015Article
- Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?World journal of experimental medicine · 2015Review
- The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2015Article
- Use of biomarkers in pediatric sepsis: literature review.Revista Brasileira de terapia intensivaReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe pediatric sepsis continues to be associated with high mortality rates in children. Thus, an important area of biomedical research is to identify biomarkers that can classify sepsis severity and outcomes. The complex and heterogeneous nature of sepsis makes the prospect of the classification of sepsis severity using a single biomarker less likely. Instead, we employ machine learning techniques to validate the use of a multiple biomarkers scoring system to determine the severity of sepsis in critically ill children. The study was based on clinical data and plasma samples provided by a tertiary care center's Pediatric Intensive Care Unit (PICU) from a group of 45 patients with varying sepsis severity at the time of admission. Canonical Correlation Analysis with the Forward Selection and Random Forests methods identified a particular set of biomarkers that included Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), and Bicarbonate (HCO[Formula: see text]) as having the strongest correlations with sepsis severity. The robustness and effectiveness of these biomarkers for classifying sepsis severity were validated by constructing a linear Support Vector Machine diagnostic classifier. We also show that the concentrations of Ang-1, Ang-2, and HCO[Formula: see text] enable predictions of the time dependence of sepsis severity in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.