ArticlePloS one2014
Functional expression of T-type Ca2+ channels in spinal motoneurons of the adult turtle.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Personalized mapping of inhibitory spinal cord circuits in humans via noninvasive neural decoding and in silico modeling.Science advances · 2025Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.The Journal of physiology · 2023Article
- Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.bioRxiv : the preprint server for biology · 2023Article
- Electrophysiological and computational analysis of CaMolecular brain · 2022Article
- A link between agrin signalling and CaScientific reports · 2022Article
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of CaNeuroscience · 2021Article
- Targeting T-type/CaV3.2 channels for chronic pain.Translational research : the journal of laboratory and clinical medicine · 2021Review
- A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of CaMolecular brain · 2020Article
- Cdk5-Dependent Phosphorylation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Genetic T-type calcium channelopathies.Journal of medical genetics · 2020Review
- Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy.Channels (Austin, Tex.) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated Ca2+ (CaV) channels are transmembrane proteins comprising three subfamilies named CaV1, CaV2 and CaV3. The CaV3 channel subfamily groups the low-voltage activated Ca2+ channels (LVA or T-type) a significant role in regulating neuronal excitability. CaV3 channel activity may lead to the generation of complex patterns of action potential firing such as the postinhibitory rebound (PIR). In the adult spinal cord, these channels have been found in dorsal horn interneurons where they control physiological events near the resting potential and participate in determining excitability. In motoneurons, CaV3 channels have been found during development, but their functional expression has not yet been reported in adult animals. Here, we show evidence for the presence of CaV3 channel-mediated PIR in motoneurons of the adult turtle spinal cord. Our results indicate that Ni2+ and NNC55-0396, two antagonists of CaV3 channel activity, inhibited PIR in the adult turtle spinal cord. Molecular biology and biochemical assays revealed the expression of the CaV3.1 channel isotype and its localization in motoneurons. Together, these results provide evidence for the expression of CaV3.1 channels in the spinal cord of adult animals and show also that these channels may contribute to determine the excitability of motoneurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.