ArticleJournal of the American Chemical Society2014
Large-scale detection of metals with a small set of fluorescent DNA-like chemosensors.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 57 citations in OpenAlex.
- Luminescent Lanthanide Probes for Inorganic and Organic Phosphates.Chemistry, an Asian journal · 2022Review
- A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene-metal-ion contact.Communications chemistry · 2021Article
- Efficient one-pot synthesis and dehydrogenation of tricyclic dihydropyrimidines catalyzed by OMS-2-SORSC advances · 2021Article
- Luminescent Carbon Dot Mimics Assembled on DNA.Journal of the American Chemical Society · 2017Article
- Color-Change Photoswitching of an Alkynylpyrene Excimer Dye.Angewandte Chemie (International ed. in English) · 2017Article
- DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases.Organic & biomolecular chemistry · 2017Article
- A Miniaturized Therapeutic Chromophore for Multiple Metal Pollutant Sensing, Pathological Metal Diagnosis and Logical Computing.Scientific reports · 2016Article
- Spinach RNA aptamer detects lead(II) with high selectivity.Chemical communications (Cambridge, England) · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An important advantage of pattern-based chemosensor sets is their potential to detect and differentiate a large number of analytes with only few sensors. Here we test this principle at a conceptual limit by analyzing a large set of metal ion analytes covering essentially the entire periodic table, employing fluorescent DNA-like chemosensors on solid support. A tetrameric "oligodeoxyfluoroside" (ODF) library of 6561 members containing metal-binding monomers was screened for strong responders to 57 metal ions in solution. Our results show that a set of 9 chemosensors could successfully discriminate the 57 species, including alkali, alkaline earth, post-transition, transition, and lanthanide metals. As few as 6 ODF chemosensors could detect and differentiate 50 metals at 100 μM; sensitivity for some metals was achieved at midnanomolar ranges. A blind test with 50 metals further confirmed the discriminating power of the ODFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.