ArticleeLife2014
Gamma delta T cells recognize haptens and mount a hapten-specific response.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells.European journal of immunology · 2025Article
- The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion.Journal of neuroinflammation · 2025Article
- Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering.Cell reports · 2024Article
- γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The function of γδ T cells in humoral immune responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Engineering γδ T Cells: Recognizing and Activating on Their Own Way.Frontiers in immunology · 2022Review
- Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions.Cellular & molecular immunology · 2020Review
- Natural Self-Ligand Gamma Delta T Cell Receptors (γδTCRs) Insight: The Potential of Induced IgG.Vaccines · 2020Article
- Recognition of synthetic polyanionic ligands underlies "spontaneous" reactivity of Vγ1 γδTCRs.Journal of leukocyte biology · 2020Article
- Lymph node γδ and αβ CD8Scientific reports · 2018Article
- The Emerging Complexity of γδT17 Cells.Frontiers in immunology · 2018Review
- The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner.Nature communications · 2017Article
- A Highly Focused Antigen Receptor Repertoire Characterizes γδ T Cells That are Poised to Make IL-17 Rapidly in Naive Animals.Frontiers in immunology · 2015Article
- Editorial: "Recent Advances in Gamma/Delta T Cell Biology: New Ligands, New Functions, and New Translational Perspectives".Frontiers in immunology · 2015Article
- Phosphoantigen Presentation to TCR γδ Cells, a Conundrum Getting Less Gray Zones.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors. Here we report that small molecules, such as cyanine 3 (Cy3), a synthetic fluorescent molecule, and 4-hydroxy-3-nitrophenylacetyl (NP), one of the most noted haptens, are γδ T cell antigens, recognized directly by specific γδ TCRs. Immunization with Cy3 conjugates induces a rapid Cy3-specific γδ T cell IL-17 response. These results expand the role of small molecules and chemical modifications in immunity and underscore the role of γδ T cells as unique adaptive immune cells that couple B cell-like antigen recognition capability with T cell effector function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.