ArticlePloS one2014
Immune profile predicts survival and reflects senescence in a small, long-lived mammal, the greater sac-winged bat (Saccopteryx bilineata).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Total Immunoglobulin G Variation Through the Phenological Cycle of Migrant and Resident Lesser Long-Nosed Bats (Leptonycteris yerbabuenae) in the Drylands of Mexico and Its Relationship With Bacterial Killing-Ability of Plasma.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Interacting effects of sex and age on immune responses in a polygynous bat with male-biased mortality.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in DNA methylation in bats.Annals of the New York Academy of Sciences · 2025Article
- Variations in immune parameters with age in a wild rodent population and links with survival.Ecology and evolution · 2022Article
- Baseline of Physiological Body Temperature and Hematological Parameters in CaptiveFrontiers in physiology · 2022Article
- Disentangling interactions among mercury, immunity and infection in a Neotropical bat community.The Journal of applied ecology · 2021Article
- Fitness outcomes in relation to individual variation in constitutive innate immune function.Proceedings. Biological sciences · 2020Article
- Social effects on age-related and sex-specific immune cell profiles in a wild mammal.Biology letters · 2020Article
- Does body growth impair immune function in a large herbivore?Oecologia · 2019Article
- Effect of sex and reproductive status on the immunity of the temperate batMammalian biology = Zeitschrift fur Saugetierkunde · 2019Article
- A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus).Molecular ecology · 2018Article
- Livestock abundance predicts vampire bat demography, immune profiles and bacterial infection risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Anthropogenic food provisioning and immune phenotype: Association among supplemental food, body condition, and immunological parameters in urban environments.Ecology and evolution · 2018Article
- Immunosenescence patterns differ between populations but not between sexes in a long-lived mammal.Scientific reports · 2017Article
- Predictors and immunological correlates of sublethal mercury exposure in vampire bats.Royal Society open science · 2017Article
- Simulated bacterial infection disrupts the circadian fluctuation of immune cells in wrinkle-lipped bats (PeerJ · 2017Article
- Evolutionary ecology of aging: time to reconcile field and laboratory research.Ecology and evolution · 2016Article
- Age-related declines in immune response in a wild mammal are unrelated to immune cell telomere length.Proceedings. Biological sciences · 2016Article
- Feather bacterial load shapes the trade-off between preening and immunity in pigeons.BMC evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system imposes costs that may have to be traded against investment of resources in other costly life-history traits. Yet, it is unknown if a trade-off between immunity and longevity occurs in free-ranging mammals. Here, we tested if age and survival, two aspects associated with longevity, are linked to immune parameters in an 8 g bat species. Using a combination of cross-sectional and longitudinal data, we assessed whether total white blood cell (WBC) counts, bacterial killing ability of the plasma (BKA) and immunoglobulin G (IgG) concentration change with age. Furthermore, we asked if these immune parameters impose costs resulting in decreased survival probabilities. We found that WBC counts decreased with age both within and among individuals. IgG concentrations were higher in older individuals, but did not change with age within individuals. Furthermore, individuals with above average WBC counts or IgG concentration had lower probabilities to survive the next six months. High WBC counts and IgG concentrations may reflect infections with parasites and pathogens, however, individuals that were infected with trypanosomes or nematodes showed neither higher WBC counts or IgG concentrations, nor was infection connected with survival rates. BKA was higher in infected compared with uninfected bats, but not related to age or survival. In conclusion, cellular (WBC) and humoral (IgG) parts of the immune system were both connected to age and survival, but not to parasite infections, which supports the hypothesis that energetically costly immunological defences are traded against other costly life-history traits, leading to a reduced lifespan in this free-ranging mammal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.