ArticleAmerican journal of respiratory cell and molecular biology2015
Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages.
Article in American journal of respiratory cell and molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- A Systematic Review of Innate Immunomodulatory Effects of Household Air Pollution Secondary to the Burning of Biomass Fuels.Annals of global healthPooled it
- Early life cookstove interventions and children's blood pressure: Evidence from the Ghana randomized air pollution and health study.Environmental research · 2025Trial
- Reduced bronchoalveolar macrophage phagocytosis and cytotoxic effects after controlled short-term exposure to wood smoke in healthy humans.Particle and fibre toxicology · 2023Trial
- Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations.International journal of environmental research and public health · 2018Trial
- Spatial spillover effects and regional differences of tuberculosis health education levels among China's floating population: a spatial lag model study (2014-2017).BMC public health · 2026Article
- RNAseq analysis demonstrates polarization state-dependent responses to ambient particulate matter in a particle composition-specific manner.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Alveolar macrophage carbon is associated with COPD severity.ERJ open research · 2025Article
- Correlations between human alveolar macrophage particulate matter load, air pollution particulate matter levels, and systemic inflammation markers in Mexico City.Scientific reports · 2025Article
- How macrophage heterogeneity affects tuberculosis disease and therapy.Nature reviews. Immunology · 2025Review
- Human Monocyte-Derived Macrophages Demonstrate Distinct Responses to Ambient Particulate Matter in a Polarization State- and Particle Seasonality-Specific Manner.Chemical research in toxicology · 2025Article
- Short term air pollution exposure during pregnancy and associations with maternal immune markers.Environmental research · 2024Article
- Diesel exhaust particle extract elicits an oxPAPC-like transcriptomic profile in macrophages across multiple mouse strains.Environmental pollution (Barking, Essex : 1987) · 2024Article
- The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review.Archives of toxicology · 2024Review
- Associations between air pollutants and acute exacerbation of drug-resistant tuberculosis: evidence from a prospective cohort study.BMC infectious diseases · 2024Article
- Household air pollution and risk of pulmonary tuberculosis in HIV-Infected adults.Environmental health : a global access science source · 2024Article
- Diesel exhaust particles induce polarization state-dependent functional and transcriptional changes in human monocyte-derived macrophages.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Household Air Pollution and Risk of Pulmonary Tuberculosis in HIV-Infected Adults.Research square · 2023Article
- Reduction of household air pollution through clean fuel intervention and recovery of cellular immune balance.Environment international · 2023Article
- The possible role of particulate matter on the respiratory microbiome: evidence from in vivo to clinical studies.Archives of toxicology · 2023Review
- Air pollution and respiratory infections: the past, present, and future.Toxicological sciences : an official journal of the Society of Toxicology · 2023Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Three billion people are exposed to household air pollution from biomass fuel use. Exposure is associated with higher incidence of pneumonia, and possibly tuberculosis. Understanding mechanisms underlying these defects would improve preventive strategies. We used human alveolar macrophages obtained from healthy Malawian adults exposed naturally to household air pollution and compared them with human monocyte-derived macrophages exposed in vitro to respirable-sized particulates. Cellular inflammatory response was assessed by IL-6 and IL-8 production in response to particulate challenge; phagosomal function was tested by uptake and oxidation of fluorescence-labeled beads; ingestion and killing of Streptococcus pneumoniae and Mycobacterium tuberculosis were measured by microscopy and quantitative culture. Particulate ingestion was quantified by digital image analysis. We were able to reproduce the carbon loading of naturally exposed alveolar macrophages by in vitro exposure of monocyte-derived macrophages. Fine carbon black induced IL-8 release from monocyte-derived and alveolar macrophages (P < 0.05) with similar magnitude responses (log10 increases of 0.93 [SEM = 0.2] versus 0.74 [SEM = 0.19], respectively). Phagocytosis of pneumococci and mycobacteria was impaired with higher particulate loading. High particulate loading corresponded with a lower oxidative burst capacity (P = 0.0015). There was no overall effect on killing of M. tuberculosis. Alveolar macrophage function is altered by particulate loading. Our macrophage model is comparable morphologically to the in vivo uptake of particulates. Wood smoke-exposed cells demonstrate reduced phagocytosis, but unaffected mycobacterial killing, suggesting defects related to chronic wood smoke inhalation limited to specific innate immune functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.