ReviewInternational braz j urol : official journal of the Brazilian Society of Urology
Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination.
Review in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03477136 (Correlation of Serum and Semen Vitamin D Level With Semen Parameters in Males), which is not on this map. Cited by 76 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Correlation of Serum and Semen Vitamin D Level With Semen Parameters in Males
Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Pooled it
- Clinical Utility of Sperm Function Tests in Predicting Male Fertility: A Systematic Review.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male.International urology and nephrology · 2015Pooled it
- Effect of varicocele on semen characteristics according to the new 2010 World Health Organization criteria: a systematic review and meta-analysis.Asian journal of andrologyPooled it
- Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-associated infertility.International urology and nephrology · 2015Trial
- Sperm DNA fragmentation and its impact on pregnancy outcomes: a narrative review focusing on threshold definition and clinical strategies.Translational andrology and urology · 2026Review
- Association between sperm parameters and recurrent pregnancy loss in infertile couples: a cross-sectional study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026Article
- Comparison of upper, middle, and lower pole pathologic biopsies of the testes in patients with non-obstructive azoospermia.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Article
- The Effect of Hydroalcoholic Extract ofFood science & nutrition · 2025Article
- Prospective Assessment of Gonadotropin Therapy and Its Outcome in Nonobstructive Azoospermic Patients.Cureus · 2025Article
- The Andrological Landscape in the Twenty-First Century: Making Sense of the Advances in Male Infertility Management for the Busy Clinicians.International journal of environmental research and public health · 2024Review
- Association of Urinary Mycotoxins with Sperm Quality: A Case-Control Study in Southern Nigeria.Toxins · 2024Article
- The role of oral antioxidants in the improvement of sperm parameters in infertile men.World journal of urology · 2024Review
- Effect of environmental factors on seminal microbiome and impact on sperm quality.Frontiers in endocrinology · 2024Review
- Male infertility.Nature reviews. Disease primers · 2023Review
- Evolution of the World Health Organization semen analysis manual: where are we?Nature reviews. Urology · 2022Review
- Duration-dependent effects of high dose of phthalate exposure on semen quality in adult male rats.JBRA assisted reproduction · 2022Article
- Editorial Commentary on Draft of World Health Organization Sixth Edition Laboratory Manual for the Examination and Processing of Human Semen.The world journal of men's health · 2021Article
- A Web-Based Global Educational Model for Training in Semen Analysis during the COVID-19 Pandemic.The world journal of men's health · 2021Article
- Genetic Association of the FunctionalJournal of personalized medicine · 2021Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semen analysis is the corner stone of infertility evaluation as it provides information on the functional status of the seminiferous tubules, epididymis and accessory sex glands. The methods on how the human semen should be evaluated are provided by the World Health Organization, which periodically releases manuals that include specific protocols and reference standards. In 2010, the WHO published new criteria for human semen characteristics that were markedly lower than those previously reported. In this review initially it is discussed the limitations of semen analysis as a surrogate measure of a man's ability to father a pregnancy. Secondly, it is analyzed methodology issues that could explain why the newly released reference values were different from those earlier reported. Thirdly, it is speculated on the likely effects of the 2010 WHO criteria in the management of male infertility. Due to the several inherent limitations of semen analysis as a surrogate marker of male infertility, physicians should exercise caution when interpreting results. A template for semen analysis reports that incorporates the distribution of the semen characteristics of recent fathers in centiles rather than solely the minimum thresholds could aid clinicians to better understand how a given patient results compare with the reference population. Importantly, a male infertility evaluation must go far beyond a simple semen analysis, as it has to be complemented with a proper physical examination, a comprehensive history taking, and relevant endocrine, genetic, and other investigations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.