ReviewPLoS neglected tropical diseases2014
Eradication of yaws: historical efforts and achieving WHO's 2020 target.
Review in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal.PLoS neglected tropical diseases · 2019Pooled it
- Absence of human yaws and detection of Haemophilus ducreyi in skin ulcers of school children near wildlife protected areas in Tanzania.PLoS neglected tropical diseases · 2026Article
- Article
- Whole-genome sequencing reveals evidence for inter-species transmission of the yaws bacterium among nonhuman primates in Tanzania.PLoS neglected tropical diseases · 2025Article
- Yaws in Africa: Past, Present and Future.Diseases (Basel, Switzerland) · 2025Review
- Dietary variability and micronutrient status of individuals with Yaws infection in Ghana: A case-control study.PloS one · 2025Article
- Article
- Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients' ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes.PLoS neglected tropical diseases · 2024Article
- Is there still yaws in Nigeria? Active case search in endemic areas of southern Nigeria.PLoS neglected tropical diseases · 2023Article
- The genomes of the yaws bacterium, Treponema pallidum subsp. pertenue, of nonhuman primate and human origin are not genomically distinct.PLoS neglected tropical diseases · 2023Article
- Neglected tropical diseases in Republic of Guinea: disease endemicity, case burden and the road towards the 2030 target.International health · 2023Review
- How to find a forgotten disease like yaws: Lessons from the Philippine experience.PLoS neglected tropical diseases · 2023Article
- Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria.The American journal of tropical medicine and hygiene · 2023Article
- No evidence for yaws infection in a small-scale cross-sectional serosurvey in Ghanaian monkeys.Veterinary medicine and science · 2023Article
- Prospecting for yaws in the Mbaïki Health District in the Central African Republic.The Pan African medical journal · 2023Article
- Yaws in Pygmy and Bantu children inhabiting the rural zones of Central Africa.Postepy dermatologii i alergologii · 2022Article
- A Systematic Review on Suitability of Molecular Techniques for Diagnosis and Research into Infectious Diseases of Concern in Resource-Limited Settings.Current issues in molecular biology · 2022Review
- Diagnostics to support the eradication of yaws-Development of two target product profiles.PLoS neglected tropical diseases · 2022Article
- Mass drug administration of antibacterials: weighing the evidence regarding benefits and risks.Infectious diseases of poverty · 2022Review
- The impact of mass drug administration of antibiotics on the gut microbiota of target populations.Infectious diseases of poverty · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundYaws, one of the 17 neglected tropical diseases (NTDs), is targeted for eradication by 2020 in resolution WHA66.12 of the World Health Assembly (2013) and the WHO roadmap on NTDs (2012). The disease frequently affects children who live in poor socioeconomic conditions. Between 1952 and 1964, WHO and the United Nations Children's Fund (UNICEF) led a global eradication campaign using injectable benzathine penicillin. Recent developments using a single dose of oral azithromycin have renewed optimism that eradication can be achieved through a comprehensive large-scale treatment strategy. We review historical efforts to eradicate yaws and argue that this goal is now technically feasible using new tools and with the favorable environment for control of NTDs. We also summarize the work of WHO's Department of Control of Neglected Tropical Diseases in leading the renewed eradication initiative and call on the international community to support efforts to achieve the 2020 eradication goal. The critical factor remains access to azithromycin. Excluding medicines, the financial cost of yaws eradication could be as little as US$ 100 million.
conclusionsThe development of new tools has renewed interest in eradication of yaws; with modest support, the WHO eradication target of 2020 can be achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.