Evidence map›Paper›PMID 25254338›Full record

ArticleStem cell reports2014

Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice.

Takayuki Kondo, Misato Funayama, Kayoko Tsukita, Akitsu Hotta, Akimasa Yasuda, Satoshi Nori, Shinjiro Kaneko, Masaya Nakamura, Ryosuke Takahashi, Hideyuki Okano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 146 citations in OpenAlex.

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  8. "Time Is Brain" - for Cell Therapies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Takayuki KondoCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan.
Misato FunayamaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan.
Kayoko TsukitaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan.
Akitsu HottaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan; PRESTO, JST, Saitama 332-0012, Japan; iCeMS, Kyoto University, Kyoto 606-8507, Japan.
Akimasa YasudaDepartment of Orthopedic Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan.
Satoshi NoriDepartment of Orthopedic Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan.
Shinjiro KanekoDepartment of Orthopedic Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan; Department of Orthopaedic Surgery, National Hospital Organization, Murayama Medical Center, Tokyo 208-0011, Japan.
Masaya NakamuraDepartment of Orthopedic Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan.
Ryosuke TakahashiDepartment of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.
Hideyuki OkanoDepartment of Physiology, School of Medicine, Keio University, Tokyo 160-8582, Japan.
Shinya YamanakaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.
Haruhisa InoueCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan; CREST, JST, Saitama 332-0012, Japan. Electronic address: haruhisa@cira.kyoto-u.ac.jp.
Keio University · JPJapan Science and Technology Agency · JPKyoto University · JPGladstone Institutes · USMurayama Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transplantation of glial-rich neural progenitors has been demonstrated to attenuate motor neuron degeneration and disease progression in rodent models of mutant superoxide dismutase 1 (SOD1)-mediated amyotrophic lateral sclerosis (ALS). However, translation of these results into a clinical setting requires a renewable human cell source. Here, we derived glial-rich neural progenitors from human iPSCs and transplanted them into the lumbar spinal cord of ALS mouse models. The transplanted cells differentiated into astrocytes, and the treated mouse group showed prolonged lifespan. Our data suggest a potential therapeutic mechanism via activation of AKT signal. The results demonstrated the efficacy of cell therapy for ALS by the use of human iPSCs as cell source.

Indexed as

Amyotrophic Lateral SclerosisAnimalsAstrocytesCell DifferentiationDisease Models, AnimalHumansInduced Pluripotent Stem CellsKaplan-Meier EstimateMiceMice, TransgenicNerve Growth FactorsNeural Stem CellsProto-Oncogene Proteins c-aktSignal TransductionSpinal CordSuperoxide DismutaseNerve Growth FactorsProto-Oncogene Proteins c-aktSuperoxide Dismutase

Identifiers

PMID25254338
PMCPMC4175543
OpenAlexW2160249662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.