ArticleStem cell reports2014
Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Stem cell competition.Current topics in developmental biology · 2026Review
- Spermatogonial Stem Cells in Domestic Animals: Current Insights and Future Directions with a Focus on Dogs.Veterinary sciences · 2025Review
- Prevalence and genetics of "de novo" MEN2 syndromes.The Journal of clinical endocrinology and metabolism · 2025Article
- Mechanisms of Germline Stem Cell Competition across Species.Life (Basel, Switzerland) · 2024Review
- SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.Biology of reproduction · 2023Article
- Viral Transduction of Mammalian Spermatogonial Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling.Cell proliferation · 2021Article
- Timing of spermatogonial stem cell transplantation affects the spermatogenic recovery outcome in mice.In vitro cellular & developmental biology. Animal · 2021Article
- Loss of tyrosine kinase receptor Ephb2 impairs proliferation and stem cell activity of spermatogonia in culture†.Biology of reproduction · 2020Article
- Expression and functional analyses of ephrin type-A receptor 2 in mouse spermatogonial stem cells†.Biology of reproduction · 2020Article
- The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors.Human reproduction (Oxford, England) · 2019Article
- Functional robustness of adult spermatogonial stem cells after induction of hyperactive Hras.PLoS genetics · 2019Article
- Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes.Genome research · 2018Article
- Spermatogonial stem cells.Biology of reproduction · 2018Review
- Male germ cells support long-term propagation of Zika virus.Nature communications · 2018Article
- Faithful Artificial Chromosome Propagation Using Spermatogonial Stem Cells.Trends in genetics : TIG · 2017Article
- Spermatogonial Stem Cells: Implications for Genetic Disorders and Prevention.Stem cells and development · 2016Article
- Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers.Annual review of genomics and human genetics · 2016Review
- Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genetics of gonadal stem cell renewal.Annual review of cell and developmental biology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Pathogenic de novo mutations increase with fathers' age and could be amplified through competition between genetically distinct subpopulations of spermatogonial stem cells (SSCs). Here, we tested the fitness of SSCs bearing wild-type human FGFR2 or an Apert syndrome mutant, FGFR2 (S252W), to provide experimental evidence for SSC competition. The S252W allele conferred enhanced FGFR2-mediated signaling, particularly at very low concentrations of ligand, and also subtle changes in gene expression. Mutant SSCs exhibited improved competitiveness in vitro and increased stem cell activity in vivo upon transplantation. The fitness advantage in vitro only occurred in low concentrations of fibroblast growth factor (FGF), was independent of FGF-driven proliferation, and was accompanied by increased response to glial cell line-derived neurotrophic factor (GDNF). Our studies provide experimental evidence of enhanced stem cell fitness in SSCs bearing a paternal age-associated mutation. Our model will be useful for interrogating other candidate mutations in the future to reveal mechanisms of disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.