Evidence map›Paper›PMID 25254174›Full record

ReviewWorld journal of clinical pediatrics2013

Bacterial colonization and intestinal mucosal barrier development.

Xiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li, Jing Lin

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of clinical pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

  1. CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025
    Review
  2. Article
  3. Influence of dietaryTranslational animal science · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Inhibition of AMediators of inflammation · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Steroids, stress and the gut microbiome-brain axis.Journal of neuroendocrinology · 2018
    Review
  17. Article
  18. Article
  19. Review
  20. Reevaluating the hype: four bacterial metabolites under scrutiny.European journal of microbiology & immunology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiao-Zhong HuangXiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li, Jing Lin, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Li-Bin ZhuXiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li, Jing Lin, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Zhong-Rong LiXiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li, Jing Lin, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Jing LinXiao-Zhong Huang, Li-Bin Zhu, Zhong-Rong Li, Jing Lin, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal tract is colonized soon after birth with a variety of ingested environmental and maternal microflora. This process is influenced by many factors including mode of delivery, diet, environment, and the use of antibiotics. Normal intestinal microflora provides protection against infection, ensures tolerance to foods, and contributes to nutrient digestion and energy harvest. In addition, enteral feeding and colonization with the normal commensal flora are necessary for the maintenance of intestinal barrier function and play a vital role in the regulation of intestinal barrier function. Intestinal commensal microorganisms also provide signals that foster normal immune system development and influence the ensuing immune responses. There is increasingly recognition that alterations of the microbial gut flora and associated changes in intestinal barrier function may be related to certain diseases of the gastrointestinal tract. This review summarizes recent advances in understanding the complex ecosystem of intestinal microbiota and its role in regulating intestinal barrier function and a few common pediatric diseases. Disruption in the establishment of a stable normal gut microflora may contribute to the pathogenesis of diseases including inflammatory bowel disease, nosocomial infection, and neonatal necrotizing enterocolitis.

Indexed as

Bacterial colonizationIntestinal barrierIntestinal microfloraMicrobiotaNeonatal necrotizing enterocolitisNosocomial infectionPremature infantsShort chain fatty acids

Identifiers

PMID25254174
PMCPMC4145654
OpenAlexW2087519383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.